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I. Harb
Researcher at McGill University
Publications - 2
Citations - 90
I. Harb is an academic researcher from McGill University. The author has contributed to research in topics: Nonribosomal peptide & Protein domain. The author has an hindex of 2, co-authored 2 publications receiving 45 citations.
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Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility.
TL;DR: The structures and small-angle x-ray scattering showNRPSs undergo very large conformational changes and challenge the general assumption that NRPSs have regular higher-order architecture, as well as direct coupling analyses used to confirm the biological relevance and evolutionary conservation of observed interdomain interfaces.
Journal ArticleDOI
Structural insight into a novel formyltransferase and evolution to a nonribosomal peptide synthetase tailoring domain.
TL;DR: The structures of the FT reveal insights into the adaptations that were needed to co-opt and evolve a sugar FT into a functional and useful NRPS domain.