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I. I. Ganusevich
Researcher at National Academy of Sciences of Ukraine
Publications - 20
Citations - 255
I. I. Ganusevich is an academic researcher from National Academy of Sciences of Ukraine. The author has contributed to research in topics: Cancer & Superoxide. The author has an hindex of 9, co-authored 19 publications receiving 232 citations.
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Journal ArticleDOI
Hypoxia, tumour-associated macrophages, microvessel density, VEGF and matrix metalloproteinases in human gastric cancer: interaction and impact on survival.
S. Osinsky,L Bubnovskaya,I. I. Ganusevich,Antonina Kovelskaya,Lilya Gumenyuk,Gennadij Olijnichenko,Sergej Merentsev +6 more
TL;DR: The overall survival rate of patients with strong tumour hypoxia, high level of MVD, VEGF expression, TAM and MMP activity was significantly lower than that of the patients without the mentioned tumour characteristics.
Journal Article
Selectivity of effects of redox-active cobalt(III) complexes on tumor tissue.
Sergey Osinsky,Ilia Levitin,L Bubnovskaya,Andrey Sigan,I. I. Ganusevich,Antonina Kovelskaya,Natalya Valkovskaya,Luigi Campanella,Peter Wardman +8 more
TL;DR: Cobalt(III) complexes affect tumor tissue with a very high level of selectivity; in particular they activate lipid peroxidation, induce DNA single-strand breaks, suppress the bioenergetic status, and enhance hypoxia.
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Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth
TL;DR: It is shown that the activity of M MP-2 and MMP-9 in tumor tissue correlate with the superoxide radicals generation rate and NO levels, and the feasibility of ESR to locally determine oxidative stress is demonstrated.
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Colorectal Cancer and Mitochondrial Dysfunctions of the Adjunct Adipose Tissues: A Case Study.
TL;DR: Redox state-superoxide generation rate, activity of complex I in electron transport chain (ETC) of mitochondria and of dinitrosyl iron complexes by electron paramagnetic resonance, and Gelatinase activity in ATAT are investigated for better understanding the mechanism(s) of metabolic symbiosis of tumor and AT as well as serving as a basis for new therapeutic approaches.
Journal ArticleDOI
Redox-active cobalt complexes as promising antitumor agents
S. Osinsky,I. Ya. Levitin,A. L. Sigan,L Bubnovskaya,I. I. Ganusevich,Luigi Campanella,P. Wardman +6 more
TL;DR: Cobalt(iii) complexes with tetradentate aliphatic Schiff"s bases containing also compounds of the vitamin PP series or their analogs as axial ligands were synthesized as potential antitumor agents and exhibit a strong antimetastatic effect.