I. M. Burr

TL;DR: It is concluded that the β-cytotoxic effect of streptozotocin is not immediately irreversible or that it does not affect all B-cells simultaneously; that the insulin release observed between 6 and 10 hr after the injection of strePTozotOCin occurs by way of leakage from damaged B- cells; and that streptozootoc in and alloxan differ in their mechanism of action on the pancreatic B-cell.

TL;DR: This chapter provides an overview of spontaneous hyperglycemia and/or obesity in laboratory rodents and observations related to the heredity of the syndromes emphasize the need for caution in considering any theory of the pathogenesis of diabetes based on a single and genetically simple anomaly.

TL;DR: Dynamic insulin release studies have now become possible, however, and the preparation may well be particularly favorable in that it may allow for the as yet indirect characterization of a cyclic AMP effect on the maturation of fetal insulin release mechanisms.

TL;DR: Over the last few decades, considerable progress has been made in understanding biochemical abnormalities associated with clinical diabetes, particularly with its more short-term manifestations, but awareness of the unsatisfactory state of the authors' understanding of other, more chronic and less clearly biochemical problems in diabetics has increased rather than decreased.

TL;DR: Estimates indicate that proinsulin is released from rat pancreas during constant glucose stimulation in vitro, and release was detectable within 30-40 minutes of stimulation.