The role of oxidized lipoproteins in atherogenesis

Mammalian nitric oxide synthases.

Tetrahedron report number 221

Isoforms of nitric oxide synthase Characterization and purification from different cell types

▪ Abstract The product of nitric oxide (NO) synthase is the most potent endogenous vasodilator known. NO not only is a potent vasodilator, it also inhibits platelet adherence and aggregation, reduc...

http://www3.uah.es/farmamol/Public/AnnReviews/PDF/Medicine/NO_synthase.pdf

Nitric oxide synthase: role in the genesis of vascular disease.

Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues.

Seventeen 2-aryl-3-haloallylamine derivatives were prepared and evaluated as inhibitors of monoamine oxidase (MAO, EC 1.4.3.4). The synthesis of these compounds was achieved from either alpha-methylstyrene or ring-substituted phenylacetic acid derivatives. With one exception, these 2-arylallylamines were found to be enzyme-activated, irreversible inhibitors of MAO. The most potent inhibitors were ring-substituted derivatives of (E)-2-phenyl-3-fluoroallylamine with IC50 values ranging from 10(-6) to 10(-8) M. Selectivity for the A and B form of MAO was found to depend on the nature of aromatic ring substitution. In general, hydroxyl substitution favored the inactivation of the A form of MAO, while very selective B inhibitors were obtained when the aromatic ring was substituted with a 4-methoxy group. (E)-2-(4-Methoxyphenyl)-3-fluoroallylamine and (E)-2-(3,4-dimethoxyphenyl)-3-fluoroallylamine proved to be in vitro as selective for the B form of MAO as deprenyl.

Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships

A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages.

Characterization of cell selectivity of two novel inhibitors of nitric oxide synthesis.

L'acide 3-(4,6-dichloro-2-carboxyindol-3-yl) propionique ainsi que d'autres derives de l'acide indolepropionique representent une nouvelle classe d'antagonistes de l'acide N-methyl-D-aspartique, agissant au niveau d'un site de liaison de la glycine insensible a la strychnine

3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex.

Ian A. McDonald

Papers

Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues.

Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships

A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages.

Characterization of cell selectivity of two novel inhibitors of nitric oxide synthesis.

3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex.