Ian B. Hogue

TL;DR: It is reported that nuclear herpesvirus capsids do not use directed motility, and infection with different herpesviruses induced an enlargement of interchromatin domains and allowed particles to diffuse unrestricted over longer distances, thereby facilitating nuclear egress for a larger fraction of capsids.

TL;DR: It is found that viral glycoproteins traffic to the cell surface in association with constitutive secretory Rab GTPases and exhibit free diffusion into the plasma membrane after exocytosis, which reinforces the idea that virions and light particles share a biogenesis and trafficking pathway.

TL;DR: A mathematical model describing the dynamics of HIV-1, CD4+ and CD8+ T-cells, and DCs interacting in a human lymph node was analysed and is presented here and predicted that simultaneous priming and infection of T cells by DCs drives early infection dynamics when activated T-helper cell numbers are low.

TL;DR: A compendium of reported fluorescent protein fusions to herpes simplex virus 1 and pseudorabies virus (PRV) structural proteins is provided, the underappreciated challenges of fluorescent protein-based approaches in the context of a replicating virus are discussed, and general strategies and best practices for creating new fluorescent fusions are described.

TL;DR: The analysis suggests that macrophages play an important role during co-infection and decreases in macrophage counts are coupled to a decline in CD4 + T-cells and increased viral loads, compromising protective immunity in the lung and eventually leading to TB reactivation.