Ian C. Dickinson

TL;DR: Bone Tissue Engineering has been the topic of substantial research over the past two decades as mentioned in this paper, and recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone.

TL;DR: A strong association of malignancy with TP53 mutation, or MDM2 amplification and the presence of a G allele in SNP309 is observed, especially in lipoma versus liposarcoma, which emphasizes the critical role of p53 inactivation in sarcomagenesis.

TL;DR: The aim of the investigation was to assess the significance of the extent of surgical margin on the chance of death, metastasis and local recurrence in soft tissue sarcoma.

TL;DR: Part of the rationale and road map of how the multidisciplinary research team has approached the first steps to translate orthopedic bone engineering from bench to bedside by establishing a preclinical ovine critical-sized tibial segmental bone defect model is described.

TL;DR: In this paper, the authors present a comparison of different clinical treatment strategies currently in use for long bone defects and non-unions in a clinical trial, based on the results obtained so far in diverse animal studies, bone tissue engineering approaches need further validation in more clinically relevant animal models.