I
Ian S. Westley
Researcher at University of South Australia
Publications - 20
Citations - 867
Ian S. Westley is an academic researcher from University of South Australia. The author has contributed to research in topics: Perhexiline & Therapeutic drug monitoring. The author has an hindex of 11, co-authored 17 publications receiving 815 citations.
Papers
More filters
Journal ArticleDOI
Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference.
Pierre Wallemacq,Victor W. Armstrong,Mercè Brunet,Vincent Haufroid,David W. Holt,Atholl Johnston,Dirk Kuypers,Yannick Le Meur,Pierre Marquet,Michael Oellerich,Eric Thervet,Burkhand Toenshoff,Nas Undre,Lutz T. Weber,Ian S. Westley,Michel Mourad +15 more
TL;DR: The importance of obtaining multicenter prospective trials to assess the efficacy of alternative strategies to TAC trough concentrations is emphasized, and single time points, limited sampling strategies, and area under concentration-time curve have all been considered to determine the most appropriate sampling procedure that correlates with efficacy.
Journal ArticleDOI
Role of mrp2 in the hepatic disposition of mycophenolic acid and its glucuronide metabolites: effect of cyclosporine
TL;DR: The data suggest that CsA may also inhibit the hepatic glucuronidation of MPA in Wistar rats, and the biliary excretion of M PAGe and MPAGa seems to depend on both Mrp2 and another unidentified canalicular transporter.
Journal ArticleDOI
Evaluation of the tacrolimus II microparticle enzyme immunoassay (MEIA II) in liver and renal transplant recipients
Jan L. Cogill,Paul J. Taylor,Ian S. Westley,Raymond G. Morris,Stephen V. Lynch,Anthony G. Johnson +5 more
TL;DR: The MEIA II is an improvement on the previous MEIA I and is suitable for the therapeutic drug monitoring of tacrolimus where HPLC-MS/MS is unavailable and will have the corresponding range estimates at values of 5 and 20 microLg/L in liver or renal transplant patient samples.
Journal ArticleDOI
Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose.
TL;DR: The cis-OH-per hexiline/perhexiline concentration ratio may be useful for optimizing individual patient treatment with the antianginal agent perhexilines.
Journal ArticleDOI
Validation of a high-performance liquid chromatography method for the measurement of mycophenolic acid and its glucuronide metabolites in plasma.
TL;DR: This high-performance liquid chromatography procedure for the simultaneous quantitation of mycophenolic acid and its glucuronide metabolites in plasma using protein precipitation followed by HPLC analysis with isocratic elution and UV detection is determined to be suitable for therapeutic drug monitoring and pharmacokinetic studies of MPA.