D
Dirk Kuypers
Researcher at Katholieke Universiteit Leuven
Publications - 395
Citations - 19128
Dirk Kuypers is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 71, co-authored 367 publications receiving 16300 citations. Previous affiliations of Dirk Kuypers include Radboud University Nijmegen & Catholic University of Leuven.
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Journal ArticleDOI
Calcineurin Inhibitor Nephrotoxicity
TL;DR: The authors critically review the current evidence relating systemic blood levels of cyclosporine and tacrolimus to calcineurin inhibitor nephrotoxicity, and summarize the data suggesting that local exposure to cycloporine or tacolimus could be more important than systemic exposure.
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Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference.
Pierre Wallemacq,Victor W. Armstrong,Mercè Brunet,Vincent Haufroid,David W. Holt,Atholl Johnston,Dirk Kuypers,Yannick Le Meur,Pierre Marquet,Michael Oellerich,Eric Thervet,Burkhand Toenshoff,Nas Undre,Lutz T. Weber,Ian S. Westley,Michel Mourad +15 more
TL;DR: The importance of obtaining multicenter prospective trials to assess the efficacy of alternative strategies to TAC trough concentrations is emphasized, and single time points, limited sampling strategies, and area under concentration-time curve have all been considered to determine the most appropriate sampling procedure that correlates with efficacy.
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Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome
Véronique Frémeaux-Bacchi,Marie-Agnès Dragon-Durey,Jacques Blouin,C Vigneau,Dirk Kuypers,Bernard Boudailliez,Chantal Loirat,Eric Rondeau,Wolf H. Fridman +8 more
TL;DR: Two complement alternative pathway proteins, factor H (FH) and recently membrane cofactor protein (CD46; MCP) have been identified as fostering the development of atypical HUS.
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Therapeutic drug monitoring of mycophenolate mofetil in transplantation.
Teun van Gelder,Yann Le Meur,Leslie M. Shaw,Michael Oellerich,David DeNofrio,Curtis Holt,David W. Holt,Bruce Kaplan,Dirk Kuypers,Bruno Meiser,Burkhard Toenshoff,Richard D. Mamelok +11 more
TL;DR: A roundtable meeting to discuss the use of therapeutic drug monitoring (TDM) to guide immunosuppression with mycophenolate mofetil was held in New York in December 2004, and it was agreed that TDM might help optimize outcomes, especially in patients at higher risk of rejection.
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Natural history of parathyroid function and calcium metabolism after kidney transplantation: a single-centre study
TL;DR: Kidney transplant recipients with a high iPTH and calcium x phosphate product at the time of transplantation are at risk for persistent hyperparathyroidism, especially when renal function is suboptimal.