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Ian W. Dawes
Researcher at University of New South Wales
Publications - 205
Citations - 11719
Ian W. Dawes is an academic researcher from University of New South Wales. The author has contributed to research in topics: Saccharomyces cerevisiae & Gene. The author has an hindex of 60, co-authored 205 publications receiving 11127 citations. Previous affiliations of Ian W. Dawes include Brandeis University & University of Edinburgh.
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Cells have distinct mechanisms to maintain protection against different reactive oxygen species: Oxidative-stress-response genes
TL;DR: The complete set of viable deletion strains in Saccharomyces cerevisiae was screened for sensitivity of mutants to five oxidants to identify cell functions involved in resistance to oxidative stress, highlighting the specificity of cellular responses to different oxidants.
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Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis
Peter Laun,Alena Pichová,Frank Madeo,Jörg Fuchs,Adolf Ellinger,Sepp D. Kohlwein,Ian W. Dawes,Kai-Uwe Fröhlich,Michael Breitenbach +8 more
TL;DR: It is shown by staining with dihydrorhodamine that old yeast mother cells isolated by elutriation, but not young cells, contain ROS that are localized in the mitochondria, pointing to a role for oxygen in the yeast ageing process.
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Complex cellular responses to reactive oxygen species
TL;DR: Genome-wide analyses of yeast provide insight into cellular responses to reactive oxygen species (ROS), but no one oxidant is representative of 'oxidative stress' despite the widespread use of a single compound such as H(2)O(2).
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Reactive oxygen species and yeast apoptosis.
TL;DR: The nature of the ROS involved, the damage they cause to cells, the responses of S. cerevisiae to ROS are summarised, and those aspects in which ROS affect cell integrity that may be relevant to the apoptotic process are discussed.
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Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae.
TL;DR: The experiments address the requirement for GSH in yeast, and its role in protection against oxidative stress, and it is shown that GSH is essential only as a reductant during normal cellular processes.