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Iara Fabricia Kretzer
Researcher at Universidade Federal de Santa Catarina
Publications - 15
Citations - 243
Iara Fabricia Kretzer is an academic researcher from Universidade Federal de Santa Catarina. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 8, co-authored 11 publications receiving 190 citations. Previous affiliations of Iara Fabricia Kretzer include University of São Paulo.
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Novel formulation of a methotrexate derivative with a lipid nanoemulsion
Juliana A Moura,Claudete J. Valduga,Elaine R. Tavares,Iara Fabricia Kretzer,Durvanei Augusto Maria,Raul C. Maranhão +5 more
TL;DR: LDE-ddMTX was stable, and uptake of the formulation by neoplastic cells was remarkably greater than of methotrexate, which resulted in markedly greater cytotoxicity, and LDE- ddMTX is thus a promising formulation to be tested in future animal models of cancer or rheumatic disease.
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Drug-targeting in combined cancer chemotherapy: tumor growth inhibition in mice by association of paclitaxel and etoposide with a cholesterol-rich nanoemulsion
TL;DR: The combined chemotherapy with PTX and ETP associated with LDE showed markedly superior anti-cancer properties and reduced toxicity compared to PTX + ETP.
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Hepatitis C Worldwide and in Brazil: Silent Epidemic—Data on Disease including Incidence, Transmission, Prevention, and Treatment
Iara Fabricia Kretzer,Andréa do Livramento,Joel da Cunha,Sabrina Gonçalves,Iraci Tosin,Celso Spada,Arício Treitinger +6 more
TL;DR: This review aims to summarize the available data on hepatitis C epidemiology and current status of efforts in prevention and infection control around the world and in Brazil.
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Simvastatin increases the antineoplastic actions of paclitaxel carried in lipid nanoemulsions in melanoma-bearing mice
TL;DR: Simva increased the antitumor activity of PTX carried in LDE but not ofPTX commercial presentation, possibly because statins increase the expression of LDL receptors that internalize LDE-PTX.
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Association of daunorubicin to a lipid nanoemulsion that binds to low‐density lipoprotein receptors enhances the antitumour action and decreases the toxicity of the drug in melanoma‐bearing mice
Thais C. Contente,Iara Fabricia Kretzer,Fabíola Branco Filippin-Monteiro,Durvanei Augusto Maria,Raul C. Maranhão +4 more
TL;DR: To test the toxicity and antitumoral activity of the compound N‐oleyl‐daunorubicin (oDNR) with a cholesterol‐rich nanoemulsion (LDE) formulation, a new formulation called LDE-DNR is introduced.