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Iasmina Marcovici
Publications - 21
Citations - 228
Iasmina Marcovici is an academic researcher. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 4, co-authored 14 publications receiving 61 citations.
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Journal ArticleDOI
Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy.
Cristina Dehelean,Iasmina Marcovici,Codruta Soica,Marius Mioc,Dorina Coricovac,Stela Iurciuc,Octavian Cretu,Iulia Pinzaru +7 more
TL;DR: In this article, a comprehensive perspective of the first blockbuster chemotherapeutic agents of natural origin's (e.g. taxol, vincristine, doxorubicin) mechanism of action using 3D representation is presented.
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SARS-CoV-2: Repurposed drugs and novel therapeutic approaches—insights into chemical structure—biological activity and toxicological screening
Cristina Dehelean,Voichita Lazureanu,Dorina Coricovac,Marius Mioc,Roxana Oancea,Iasmina Marcovici,Iulia Pinzaru,Codruta Soica,Aristidis Tsatsakis,Octavian Cretu +9 more
TL;DR: A thorough analysis of repurposed drug admitted for compassionate use from a chemical structure—biological activity perspective highlighting the ADME ( absorption, distribution, metabolism, and excretion) properties and the toxicophore groups linked to potential adverse effects is presented.
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Experimental Models of Hepatocellular Carcinoma-A Preclinical Perspective.
Alexandru Blidisel,Iasmina Marcovici,Dorina Coricovac,Florin Hut,Cristina Dehelean,Octavian Cretu +5 more
TL;DR: In this article, a review of the currently available preclinical models frequently applied for the study of hepatocellular carcinoma in terms of initiation, development, and progression, as well as for the discovery of efficient treatments, highlighting the advantages and the limitations of each model.
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High Concentrations of Aspartame Induce Pro-Angiogenic Effects in Ovo and Cytotoxic Effects in HT-29 Human Colorectal Carcinoma Cells.
Anca Laura Maghiari,Dorina Coricovac,Iulia Pinzaru,Ioana Macașoi,Iasmina Marcovici,Sebastian Simu,Dan Navolan,Cristina Dehelean +7 more
TL;DR: The in vitro results showed a dose-dependent cytotoxic effect, with a significant decrease of viable cells at the highest concentrations tested and morphological cellular changes, and new directions of research regarding aspartame’s role in colorectal cancer are suggested.
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Proniosomal Gel for Topical Delivery of Rutin: Preparation, Physicochemical Characterization and In Vitro Toxicological Profile Using 3D Reconstructed Human Epidermis Tissue and 2D Cells.
Iulia Pinzaru,Alina Tanase,Virgil Enatescu,Dorina Coricovac,Flavia Bociort,Iasmina Marcovici,Claudia Watz,Lavinia Vlaia,Codruta Soica,Cristina Dehelean +9 more
TL;DR: In this paper, a novel formulation for Rutin as a proniosomal gel for cutaneous applications was proposed, which was prepared by coacervation phase-separation method and complies with the standard requirements in terms of particle size (140.5 ± 2.56 nm), zeta potential (-27.33 ± 0.09 mV), encapsulation capacity (> 50%), pH (7.002 ±0.18) and rheological properties.