Iasmina Marcovici

TL;DR: In this article, a comprehensive perspective of the first blockbuster chemotherapeutic agents of natural origin's (e.g. taxol, vincristine, doxorubicin) mechanism of action using 3D representation is presented.

TL;DR: A thorough analysis of repurposed drug admitted for compassionate use from a chemical structure—biological activity perspective highlighting the ADME ( absorption, distribution, metabolism, and excretion) properties and the toxicophore groups linked to potential adverse effects is presented.

TL;DR: In this article, a review of the currently available preclinical models frequently applied for the study of hepatocellular carcinoma in terms of initiation, development, and progression, as well as for the discovery of efficient treatments, highlighting the advantages and the limitations of each model.

TL;DR: The in vitro results showed a dose-dependent cytotoxic effect, with a significant decrease of viable cells at the highest concentrations tested and morphological cellular changes, and new directions of research regarding aspartame’s role in colorectal cancer are suggested.

TL;DR: In this paper, a novel formulation for Rutin as a proniosomal gel for cutaneous applications was proposed, which was prepared by coacervation phase-separation method and complies with the standard requirements in terms of particle size (140.5 ± 2.56 nm), zeta potential (-27.33 ± 0.09 mV), encapsulation capacity (> 50%), pH (7.002 ±0.18) and rheological properties.