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Ichiro Ieiri
Researcher at Kyushu University
Publications - 194
Citations - 8859
Ichiro Ieiri is an academic researcher from Kyushu University. The author has contributed to research in topics: Population & Pharmacokinetics. The author has an hindex of 48, co-authored 173 publications receiving 8175 citations. Previous affiliations of Ichiro Ieiri include University of Tokyo & Tottori University.
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Journal Article
Expression of P-glycoprotein in human placenta : relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene
Mizuho Tanabe,Ichiro Ieiri,Naoki Nagata,Kazuko Inoue,Soichiro Ito,Yasunobu Kanamori,Masakuni Takahashi,Yasuo Kurata,Junzo Kigawa,Shun Higuchi,Naoki Terakawa,Kenji Otsubo +11 more
TL;DR: Although it remains to be determined whether these SNPs influence the pharmacokinetic and dynamic properties of clinically useful drugs that are substrates of PGP, the polymorphism of the MDR-1 gene presented here may provide useful information in in vivo study of these issues.
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Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.
Yohei Nishizato,Ichiro Ieiri,Hiroshi Suzuki,Miyuki Kimura,Kiyoshi Kawabata,Takeshi Hirota,Hiroshi Takane,Shin Irie,Hiroyuki Kusuhara,Yoko Urasaki,Akinori Urae,Shun Higuchi,Kenji Otsubo,Yuichi Sugiyama +13 more
TL;DR: The objective was to quantitate the contribution of the genetic polymorphisms of the genes for 2 human organic anion transporters—organic anion transporting polypeptide C (OATP‐C) and organic anions transporter 3 ( OAT3)—to the pharmacokinetics of pravastatin.
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Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans
Harumi Takahashi,Grant R. Wilkinson,Edith A. Nutescu,Takashi Morita,Marylyn D. Ritchie,Maria Gabriella Scordo,Vittorio Pengo,Martina Barban,Roberto Padrini,Ichiro Ieiri,Kenji Otsubo,Toshitaka Kashima,Sosuke Kimura,Shinichi Kijima,Hirotoshi Echizen +14 more
TL;DR: Japanese are more susceptible to inhibition of NPT production by S-warfarin than the other two populations, and VKORC1 and CYP2C9 polymorphisms contribute to inter-population difference in warfarin doses among the three populations, but their contribution to intra-population variability may differ within each population.
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Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein
Yasuo Kurata,Yasuo Kurata,Ichiro Ieiri,Ichiro Ieiri,Miyuki Kimura,Miyuki Kimura,Toshihiro Morita,Toshihiro Morita,Shin Irie,Shin Irie,Akinori Urae,Akinori Urae,Shigehiro Ohdo,Shigehiro Ohdo,Hisakazu Ohtani,Hisakazu Ohtani,Yasufumi Sawada,Yasufumi Sawada,Shun Higuchi,Shun Higuchi,Kenji Otsubo,Kenji Otsubo +21 more
TL;DR: The objective was to quantitate the contribution of the genetic polymorphism of the human MDR1 gene to the bioavailability and interaction profiles of digoxin, a substrate of P‐glycoprotein.
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Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.
Daisuke Kobayashi,Ichiro Ieiri,Takeshi Hirota,Hiroshi Takane,Shinji Maegawa,Junzo Kigawa,Hiroshi Suzuki,Eiji Nanba,Mitsuo Oshimura,Naoki Terakawa,Kenji Otsubo,Kazunori Mine,Yuichi Sugiyama +12 more
TL;DR: The results suggest that 1) the predominant allelic expression pattern of BCRP in placental samples is biallelic, and 2) the mutation C421A is not a genetic variant acting in cis, but is considered to influence the translation efficiency.