Showing papers by "Ichiro Ono published in 1998"
TL;DR: Results indicated that rhBMP-2, even in a small dose, increases the strength of porous HAP, which is basically a ceramic and thus has the characteristic disadvantage of being fragile, at a relatively early stage following implantation as the result of bone ingrowth to the pores of HAP.
Abstract: Combinations of hydroxyapatite (HAP) and bone morphogenetic protein (BMP) are anticipated to provide potent alternatives to autogenous bone grafts. In this study, porous HAP rods were treated with 1 μg or 5 μg of rhBMP-2 subperiosteally implanted on the cranial bone of rabbits. The HAP rods were then removed 3, 6, or 9 weeks after implantation and subjected to physical strength determinations. Even the control group, without addition of rhBMP-2 to the rods, demonstrated significantly increased three-point bending strength at 9 weeks compared with that before implantation. Groups receiving rhBMP-2-treated rods showed significant increases in strength beginning at 3 weeks. In histological examination, a slight degree of bone formation was seen around the HAP rods in the control group; however, clearly visible bone formation was found penetrating the rod pores of the rhBMP-2 groups. Histological examination also revealed that bone formation was inclined to be greater at the higher dose, 5 μg, of rhBMP-2. Results indicated that rhBMP-2, even in a small dose, increases the strength of porous HAP, which is basically a ceramic and thus has the characteristic disadvantage of being fragile, at a relatively early stage following implantation as the result of bone ingrowth to the pores of HAP.
21 citations