Y
Yoshinori Kuboki
Researcher at Hokkaido University
Publications - 176
Citations - 6493
Yoshinori Kuboki is an academic researcher from Hokkaido University. The author has contributed to research in topics: Bone morphogenetic protein & Type I collagen. The author has an hindex of 40, co-authored 176 publications receiving 6245 citations. Previous affiliations of Yoshinori Kuboki include Xinxiang Medical University & Sapporo Medical University.
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Pore Size of Porous Hydroxyapatite as the Cell-Substratum Controls BMP-Induced Osteogenesis
TL;DR: This study is the first demonstration that a matrix with a certain geometrical size is most favorable for cell differentiation and indicates that the optimal pore size for attachment, differentiation and growth of osteoblasts and vascularization is approximately 300-400 microns.
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BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: topology of osteogenesis.
Yoshinori Kuboki,Hiroko Takita,Daiji Kobayashi,Eichi Tsuruga,M. Inoue,M. Murata,Noriyuki Nagai,Yoshiko Dohi,Hajime Ohgushi +8 more
TL;DR: Results indicate that the geometry of the interconnected porous structure in PPHAP and coral-HAP create spaces for vasculature that lead to osteogenesis while the smooth structure and close contact of particles in SPHAP inhibit vascular formation and proliferation of mesenchymal cells, preventing bone and cartilage formation.
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Geometry of carriers controlling phenotypic expression in BMP-induced osteogenesis and chondrogenesis.
TL;DR: The analysis of causative factors inducing osteogenesis and chondrogenesis in the BMP system concluded that the geometry of the carrier is crucially important and vasculature-inducing geometry should be considered in designing effective scaffolds for bone formation.
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Type I collagen‐induced osteoblastic differentiation of bone‐marrow cells mediated by collagen‐α2β1 integrin interaction
TL;DR: It is shown that type I collagen matrix gels induce osteoblastic differentiation of bone marrow cells with high alkaline phosphatase activity, collagen synthesis, and formed mineralized tissues with anti‐α 2 integrin antibody, which interacts with α subunit of Integrin and blocks the binding of integrin with collagen.
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Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen.
TL;DR: Findings imply that the collagen-alpha2beta1 integrin interaction is an important signal for the osteoblastic differentiation of bone marrow cells.