Over the past decades, thermoablative techniques for the therapy of localized tumors have gained importance in the treatment of patients not eligible for surgical resection Anecdotal reports have described spontaneous distant tumor regression after thermal ablation, indicating a possible involvement of the immune system, hence an induction of antitumor immunity after thermoinduced therapy In recent years, a growing body of evidence for modulation of both adaptive and innate immunity, as well as for the induction of danger signals through thermoablation, has emerged Induced immune responses, however, are mostly weak and not sufficient for the complete eradication of established tumors or durable prevention of disease progression, and combination therapies with immunomodulating drugs are being evaluated with promising results This article aims to summarize published findings on immune modulation through radiofrequency ablation, cryoablation, microwave ablation therapy, high-intensity focused ultrasound, and laser-induced thermotherapy

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More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer

Oral potentially malignant disorders (OPMD) are chronic conditions, which have a higher risk of transformation to oral squamous cell carcinoma. The aim of this systematic review and meta-analysis was to answer the question: "What is the prevalence of oral potentially malignant disorders among adults?" Studies reporting the prevalence of these conditions (leukoplakia, erythroplakia, oral submucous fibrosis [OSMF], and actinic cheilitis) were selected, only studies in which a clinical assessment and histopathological confirmation were performed were included. Of the 5513 studies, 22 met the inclusion criteria for qualitative and quantitative analyses. The risk of bias (RoB) of the selected studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data. Seven studies were classified as high risk, 12 as moderate risk, and 3 as low RoB. The meta-analysis showed that the prevalence of OPMD was 4.47% (95% CI = 2.43-7.08). The most prevalent OPMDs were OSMF (4.96%; 95% CI = 2.28-8.62) and leukoplakia (4.11%; 95% CI = 1.98-6.97). OPMDs were identified more commonly in males (59.99%; 95% CI = 41.27-77.30). Asian and South American/Caribbean populations had the highest prevalence rates of 10.54% (95% CI = 4.60-18.55) and 3.93% (95% CI = 2.43-5.77), respectively. The overall prevalence of OPMD worldwide was 4.47%, and males were more frequently affected by these disorders. The prevalence of OPMD differs between populations; therefore, further population-based studies may contribute to the better understanding of these differences.

Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis

Cheilitis granulomatosa (CG) is a cosmetically disturbing and persistent idiopathic lip swelling. It is one manifestation of orofacial granulomatosis (OFG), which is a clinical entity describing facial and oral swelling in the setting of non-caseating granulomatous inflammation and in the absence of systemic disease such as Crohn’s disease and sarcoidosis. CG can occur by itself or as part of the Melkersson–Rosenthal syndrome, which includes facial palsy and a plicated tongue. Other proposed causes of OFG include dietary allergens such as cinnamon and benzoates. Similar orofacial swelling may be an early manifestation of Crohn’s disease or sarcoidosis, and so clinical history is important in diagnosis. The cause of CG has not been wholly elucidated, but a current hypothesis holds that a random influx of inflammatory cells is responsible. Other granulomatous and edematous causes of lip swelling must be investigated prior to diagnosis. Options for treatment include dietary modifications, antibiotics, systemic or intralesional corticosteroids, and surgery, although treatment is not always necessary. CG should be considered in the differential of persistent lip swelling.

/pdf/cheilitis-granulomatosa-a-review-3ew0oq99kk.pdf

Cheilitis Granulomatosa: A Review

Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is a rare genetic disorder that predisposes individuals to multiple cutaneous leiomyomas, renal cell carcinomas, and in women, uterine leiomyomas. Also known as Reed syndrome, it is caused by a germline heterozygous mutation of the fumarate hydratase tumor suppressor gene. HLRCC is associated with significant morbidity because of pain from cutaneous and uterine leiomyomas, the cutaneous pain often of unique character. Although genetic testing is currently considered the criterion standard to diagnose HLRCC, newer immunohistochemistry markers may provide rapid and cost effective alternatives to genetic testing. Because of the potentially aggressive nature of renal cell carcinomas that develop as early as in childhood, close annual cancer surveillance is desirable in individuals with HLRCC. In this review, we offer an update and an approach to the diagnosis, management, and renal cancer surveillance in HLRCC.

Hereditary leiomyomatosis and renal cell cancer syndrome: An update and review

Oral microbiota are among the most diverse in the human body. More than 700 species have been identified in the mouth, and new sequencing methods are allowing us to discover even more species. The anatomy of the oral cavity is different from that of other body sites. The oral cavity has mucosal surfaces (the tongue, the buccal mucosa, the gingiva, and the palate), hard tissues (the teeth), and exocrine gland tissue (major and minor salivary glands), all of which present unique features for microbiota composition. The connection between oral microbiota and diseases of the human body has been under intensive research in the past years. Furthermore, oral microbiota have been associated with cancer development. Patients suffering from periodontitis, a common advanced gingival disease caused by bacterial dysbiosis, have a 2-5 times higher risk of acquiring any cancer compared to healthy individuals. Some oral taxa, especially Porphyromonas gingivalis and Fusobacterium nucleatum, have been shown to have carcinogenic potential by several different mechanisms. They can inhibit apoptosis, activate cell proliferation, promote cellular invasion, induce chronic inflammation, and directly produce carcinogens. These microbiota changes can already be seen with potentially malignant lesions of the oral cavity. The causal relationship between microbiota and cancer is complex. It is difficult to accurately study the impact of specific bacteria on carcinoma development in humans. This review focuses on the elucidating the interactions between oral cavity bacterial microbiota and cancer. We gather literature on the current knowledge of the bacterial contribution to cancer development and the mechanisms behind it.

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Oral Microbiota and Cancer Development.

https://www.termedia.pl/Journal/-7/pdf-19663-10?filename=Solitary fibrous tumor.pdf

Case report Solitary fibrous tumor in the oral cavity: a case report and diagnostic dilemma

Interleukin 18 (IL-18) is a pleiotropic cytokine that plays a crucial role in the control of the balance between the Th1 and Th2 response. Synergistically with IL-12, IL-18 promotes an immunological response of the TH1 type, by enhancing INF-γ synthesis and inhibition of IgE production. On the other hand, IL-18 can enhance IL-4 and IL-13 production and stimulates IgE synthesis. Moreover, in the presence of IL-3, IL-18 can directly stimulate basophils and mast cells to produce their mediators. The gene of IL-18 is located on chromosome 11q22.2-22.3, which was identified as an important candidate region for susceptibility to atopy. The aim of this paper is to characterize IL-18, the evolution of views on it and to emphasize the influence of IL-18 on the development of infectious, inflammatory, autoimmune diseases and malignancies with a special consideration of atopic diseases.

https://www.termedia.pl/Journal/-7/pdf-17259-10?filename=Interleukin 18.pdf

Review paper Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response

Introduction. The epidemiology of nail apparatus tumours is not well known. They are frequently misdiagnosed because of their uncharacteristic clinical features. Objective. Evaluation the frequency and nature of nail apparatus tumours in the Northern Polish population. Material and methods. 1588 patients with various nail apparatus pathology who were diagnosed and treated in the Department of Dermatology, Venerology and Allergology of the Medical University of Gdansk from 2005 to 2010 were included in the study and 129 cases of nail apparatus tumours were diagnosed. Results. Tumours represent about 8% of nail pathology. In the majority of cases (92%) they are benign. Most frequently melanocytic lesions (41%), SŁOWA KLUCZOWE: guzy aparatu paznokciowego, czerniak aparatu paznokciowego.

https://www.termedia.pl/Journal/-56/pdf-17954-10?filename=Lagodne guzy.pdf

Benign nail apparatus tumours in the material of the Dermatology, Venerology and Allergology Department of the Medical University of Gdańsk

https://www.termedia.pl/Journal/-7/pdf-8756-1?filename=czynniki genet.pdf

Igor Michajłowski

Papers

Case report Solitary fibrous tumor in the oral cavity: a case report and diagnostic dilemma

Review paper Interleukin 18 – a pleiotropic cytokine involved in the Th1 and Th2 immunological response

Benign nail apparatus tumours in the material of the Dermatology, Venerology and Allergology Department of the Medical University of Gdańsk

Review paper Genetic factors in aetiopathogenesis of acne vulgaris

N89 Usefulness of dermoscopy for differentiation of pearly penile papules and genital warts