Ilaria Frasson

TL;DR: The results of the study show that the development of bacterial‐induced renal failure in patients with cirrhosis and ascites is related to the MELD score, and to both the severity and the lack of resolution of the infection.

TL;DR: The possibility of inhibiting the HIV-1 LTR promoter by G-quadruplex-interacting small molecules is disclosed, providing a new pathway to development of anti-HIV-1 drugs with unprecedented mechanism of action.

TL;DR: The data indicate that nucleolin possesses a specific and regulated activity toward the HIV-1 LTR promoter, which is mediated by G-quadruplexes.

TL;DR: Evidence is provided of the first evidence of the possibility to regulate HIV-1 gene expression and infectivity through G-quadruplex targeting and therefore open a new avenue for viral treatment.

TL;DR: This work synthesized naphthalene diimide derivatives with a lateral expansion of the aromatic core that were able to bind/stabilize the G-quadruplex to a high extent, and some of them displayed clear-cut selectivity toward the viral G- Quadruplexes with respect to the human telomeric G- quadruplexe.