Showing papers in "Hepatology in 2007"

TL;DR: A simple scoring system accurately separates patients with nonalcoholic fatty liver disease with and without advanced fibrosis, rendering liver biopsy for identification ofAdvanced fibrosis unnecessary in a substantial proportion of patients.

TL;DR: For values outside 1.45‐3.25, the FIB‐4 index is a simple, accurate, and inexpensive method for assessing liver fibrosis and proved to be concordant with FibroTest results.

TL;DR: Prevention and Management of Gastroesophageal Varices and Variceal Hemorrhage in Cirrhosis Guadalupe Garcia-Tsao, M.D., co-authors.

TL;DR: The Model for End‐stage Liver Disease was initially created to predict survival in patients with complications of portal hypertension undergoing elective placement of transjugular intrahepatic portosystemic shunts and was validated subsequently as an accurate predictor of survival among different populations of patients with advanced liver disease.

TL;DR: NAFLD is associated with numerous changes in the lipid composition of the liver, and the potential implications are discussed.

TL;DR: This classification has potential therapeutic implications because 50% of the tumors were related to WNT or AKT pathway activation, which potentially could be targeted by specific inhibiting therapies, and has provided specific identifiers for classifying tumors.

TL;DR: Radiofrequency ablation can be considered the treatment of choice for patients with single HCC ≤ 2.0 cm, even when surgical resection is possible, and is associated with similar survival rates and lower costs.

TL;DR: D diagnosis of HCC 20 mm or smaller can be established without a positive biopsy if both CEUS and MRI are conclusive, and these results validate the American Association for the Study of Liver Disease (AASLD) guidelines.

TL;DR: Results from this mouse model would suggest accumulation of triglycerides may be a protective mechanism to prevent progressive liver damage in NAFLD.

TL;DR: This work aims to provide a clear picture of the immune system’s role in the development of central giant cell granuloma and the role that these cells play in the progression of disease.

TL;DR: The liver is an organ with predominant innate immunity, playing an important role not only in host defenses against invading microorganisms and tumor transformation but also in liver injury and repair.

TL;DR: The ELF panel has good diagnostic accuracy in an independent validation cohort of patients with NAFLD and the addition of established simple markers augments the diagnostic performance across different stages of fibrosis, which will potentially allow superior stratification of patients for emerging therapeutic strategies.

TL;DR: LSM does not represent a reliable instrument to detect the presence of advanced fibrosis and cirrhosis in patients presenting with a clinical picture of acute hepatitis, and the extent of necroinflammatory activity needs to be carefully considered in future studies aimed at further validating transient elastography.

TL;DR: LSM represents a non‐invasive tool for the identification of chronic liver disease patients with clinically significant or severe portal hypertension and could be employed for screening patients to be subjected to standard investigations including upper GI endoscopy and hemodynamic studies.

TL;DR: A novel three‐stage method to efficiently direct the differentiation of human embryonic stem cells into hepatic cells in serum‐free medium is reported, which should facilitate searching the molecular mechanisms underlying human liver development, and form the basis for hepatocyte transplantation and drug tests.

TL;DR: The outcome of ALF varies by etiology, favorable prognoses being found with acetaminophen overdose, hepatitis A, and ischemia, and poor prognosed with drug‐induced ALF, hepatitis B, and indeterminate cases, and excellent intensive care is critical in management of patients with ALF.

TL;DR: A comprehensive molecular portrait of genomic changes in progressive HCV‐related HCC is provided, using quantitative real‐time reverse‐transcription PCR to identify new biomarkers for early HCC diagnosis.

TL;DR: In patients with HCV‐related, histologically proven cirrhosis, achievement of a SVR after IFNα therapy was associated with a reduction of liver‐related mortality lowering both the risk of complications and HCC development.

TL;DR: AIPC is a unique inflammatory disorder characterized by an immune reaction predominantly mediated by Th2 cells and Tregs, which could be characterized by the over‐production of T helper (Th) 2 and regulatory cytokines.

TL;DR: In the largest cohort to date of patients with severe AH, it is demonstrated that the term “nonresponder” can now be extended to patients with a Lille score above 0.45, which corresponds to 40% of cases.

TL;DR: In this article, the hepatitis B virus (HBV) is caused by persistent infection with HBV, a unique DNA virus that replicates through an RNA intermediate produced from a stable covalently closed circular DNA molecule.

TL;DR: The use of minimally embolic 90Y glass microspheres to treat patients with HCC complicated by branch/lobar PVT may be clinically indicated and appears to have a favorable toxicity profile.

TL;DR: The refined HCA classification and its phenotypic correlations are refined, providing a routine test to classify hepatocellular adenomas using simple and robust immunohistochemistry.

TL;DR: Adipose tissue is a source of multipotent stem cells that can be easily isolated, selected, and induced into mature, transplantable hepatocytes, and the fact that they are easy to procure ex vivo in large numbers makes them an attractive tool for clinical studies in the context of establishing an alternative therapy for liver dysfunction.

TL;DR: Treatment with lactulose improves both cognitive function and health‐related quality of life in patients with cirrhosis who have MHE and improvement in HRQOL was related to the improvement in psychometry.

TL;DR: Transient elastography frequently yields pathologically high values in patients with acute liver damage and is unsuitable for detecting cirrhosis/fibrosis in these patients.

TL;DR: A simplified spot method for determination in serum of hepatitis B virus DNA (HBV DNA) by molecular hybridization is proposed, which greatly reduced the duration of the steps preceding hybridization proper and allowed more sensitive detection in samples of only 25 or 50 m̈1.

TL;DR: A global gene expression analysis revealed that the Ath diet up‐regulated the hepatic expression levels of genes for fatty acid synthesis, oxidative stress, inflammation, and fibrogenesis, which were further accelerated by the addition of a high‐fat component.

TL;DR: A subset of microRNAs are aberrantly expressed in primary liver tumors, serving both as putative tumor suppressors and as oncogenic regulators.

TL;DR: The contribution of the Wnt/β‐catenin signaling pathway in these events is discussed and areas that are currently deficient or understudied are identified and discussed along with the avenues of translational and clinical relevance.