Showing papers by "In Ho Chang published in 2009"
TL;DR: In this cohort of healthy men hemodilution from increased plasma volume may be responsible for the observed decreased tumor marker concentration in men with a higher body mass index.
45 citations
TL;DR: The findings support the favorable role of endogenous testosterone inLower urinary tract function and suggest that testosterone deficiency may be a pathophysiological mechanism connecting lower urinary tract symptoms and the metabolic syndrome in men.
37 citations
TL;DR: A retrospective study examines the association between the metabolic syndrome (MS) and risk for the development of chronic kidney disease (CKD) in men and women over a 25-year period.
Abstract: SUMMARY
Aim: We performed a retrospective study to examine the association between the metabolic syndrome (MS) and risk for the development of chronic kidney disease (CKD).
Methods: This cohort study included 60 921 healthy adults recruited from two health promotion centres. Anthropometric measures, blood pressure, fasting glucose, lipid profile and serum creatinine were evaluated. The glomerular filtration rate was estimated (eGFR) using the abbreviated equation developed by the Modification of Diet in Renal Disease (MDRD) formula. CKD was defined as an eGFR of <60 mL/min per 1.73 m2 or the presence of proteinuria.
Results: The prevalence of MS and CKD was 19.0% and 7.2% respectively. Those with MS had a higher prevalence of CKD (11.0% vs 6.3%, P < 0.001) than those without MS. As the number of MS components increased, the prevalence of CKD increased and the eGFR decreased. The multiple linear analyses showed that each of the components of the MS was negatively correlated with the eGFR. Unadjusted and multivariate adjusted associations were identified between MS and CKD. Individuals with MS had a multivariate adjusted odds ratio of 1.680 (95% confidence interval, 0.566–1.801) for CKD compared with those without MS.
Conclusion: Our findings, which were obtained from a large Korean cohort, suggest that MS was associated with CKD.
26 citations
TL;DR: EMPD must be differentiated from benign papulosquamous disease, squamous cell carcinoma and melanoma, and can be managed by local excision and reconstruction with a skin graft or skin flap.
12 citations
TL;DR: Findings from a large Korean cohort suggest that MS was associated with CKD, and each of the components of the MS was negatively correlated with the eGFR.
12 citations
TL;DR: A downward migration of tumor grade was observed, but there were no migrations in the age of patients or clinical stage, and these findings have not contributed to changes in the cancer survival of Korean men with prostate cancer after the advent of PSA testing.
Abstract: Purpose: The aim of this study was to investigate the changes in the clinical and prognostic parameters of prostate cancer in Korean men in the eras before and after prostate-specific antigen (PSA) testing. Materials and Methods: The medical records of 303 patients treated for prostate cancer between 1982 and 2005 were reviewed with respect to age, chief complaints, clinical stage, tumor grade, treatment options, and prognosis. We classified the patients as follows: those treated in the prePSA era (1982-1995, n=81), and those treated in the PSA era (1996-2000, PSA era phase 1, n=92; and 2001-2005, PSA era phase 2, n=130). Results: There was no significant difference in age or clinical stage between patients treated before and those treated during the PSA era, although there was a downward migration of grade. The cancer-specific survival rates were also not different in all cases and in metastatic prostate cancer cases between the pre-PSA era and the PSA era, although the overall survival rates were significantly greater in all cases in phase 2 of the PSA era than in the pre-PSA era or in phase 1 of the PSA era (p＜0.05). However, the cancer-specific survival rates for localized or locally advanced prostate cancer were significantly greater in phase 2 of the PSA era than in the pre-PSA era or in phase 1 of the PSA era (p＜0.05). Conclusions: We observed a downward migration of tumor grade, but there were no migrations in the age of patients or clinical stage, and these findings have not contributed to changes in the cancer survival of Korean men with prostate cancer after the advent of PSA testing. (Korean J Urol 2009;50:439-444)
6 citations
TL;DR: The results of this study reveal that the intensity of prostate epithelial resistin expression is higher in those with PCa than inThose with BPH, and a positive association was found between the histologic grade and stage of PCa and theintensity of resistinexpression.
Abstract: Purpose: Because insulin resistance may be related to prostate cancer (PCa) initiation and progression, and adipokines target preneoplastic cells, leading to activation of signaling cascades that can promote aberrant cellular proliferation and transformation to a malignant phenotype, we hypothesized that increased resistin protein in prostate epithelial cells might underlie the association between PCa and insulin resistance. Materials and Methods: In this study, we investigated the intensity of prostate epithelial resistin expression by immunohistochemical staining in 67 patients with PCa and 26 patients with benign prostatic hyperplasia (BPH). The body mass index (BMI) and age of the groups were similar. Patients with PCa were stratified into 3 groups according to the spread of the disease as organ-confined, locally advanced, or metastatic disease and according to the grade. Results: The intensity of prostate epithelial resistin expression and the mean prostate-specific antigen (PSA) were significantly greater in the PCa group than in the BPH group. Additionally, according to progression of PCa, mean PSA, mean age, and the intensity of resistin expression were significantly increased. With higher Gleason score of PCa, age and the intensity of resistin expression were significantly increased. Conclusions: The results of our study reveal that the intensity of prostate epithelial resistin expression is higher in those with PCa than in those with BPH. A positive association was found between the histologic grade and stage of PCa and the intensity of resistin expression. (Korean J Urol 2009;50:540-546)
5 citations
TL;DR: Serum IL-6 levels are a better indicator of the severity of disease and the therapeutic effect of empirical parenteral antibiotic use in patients with acute uncomplicated pyelonephritis than were either CRP or WBC counts.
Abstract: Purpose: In this prospective study, we evaluated the clinical significance of inflammatory cytokines in women with acute uncomplicated pyelonephritis undergoing antimicrobial therapy. Materials and Methods: We analyzed 26 female patients diagnosed with acute uncomplicated pyelonephritis between September 2007 and March 2008. Body temperature, white blood cell (WBC) counts, serum C-reactive protein (CRP), and serum and urine interleukin (IL)-6 and IL-8 were measured before and 12 hours, 24 hours, and 4 days after the intravenous administration of empirical ciprofloxacin. Results: Initial serum CRP levels were correlated with initial serum IL-6 and initial urine IL-8 levels. Twenty-four hours after the start of antibiotic treatment, the CRP level and urine IL-8 level continued to be high, whereas serum IL-6 levels decreased significantly (26.1±32.4 vs 9.9±23.5pg/dl, p<0.01). When we divided the patients into mild (CRP<15mg/dl, n=14) and severe (CRP≥15mg/dl, n=12) groups according to initial CRP levels, the serum IL-6 level decreased significantly in both the mild (14.2±4.0 vs 4.0±1.7pg/dl, p<0.01) and the severe (41.1±12.7 vs. 22.7±16.4pg/dl, p<0.01) groups within 24 hours, whereas CRP and urine IL-8 levels did not change significantly in either group. Conclusions: Clinically, initial serum IL-6 and urine IL-8 levels were increased according to disease severity. Moreover, the serum IL-6 level decreased rapidly after antibiotic treatment within 24 hours. Serum IL-6 levels are a better indicator of the severity of disease and the therapeutic effect of empirical parenteral antibiotic use in patients with acute uncomplicated pyelonephritis than were either CRP or WBC counts. (Korean J Urol 2009;50:33-38)
1 citations
TL;DR: The results suggest that in the setting of persistent abnormal urine cytology with a negative initial evaluation, 53.3% of patients will later develop TCC.
Abstract: Purpose: We investigated the factors that predicted later transitional cell carcinoma (TCC) in a subgroup of patients with abnormal cytology and negative initial evaluations. Materials and Methods: From January 2002 to June 2007, we retrospectively identified 58 patients. Cases were considered discordant if a work-up of urine cytology was abnormal although initial cystoscopy, upper tract evaluation, and biopsies resulted in a negative or benign diagnosis. Patients who could complete a urine cytology test after 6 to 8 weeks and who were followed up for at least 1 year were included in this study. According to later TCC demonstration, we compared risk factors for TCC between the later TCC group and the benign group and evaluated the independent factors that predicted later TCC by use of a Cox proportional hazards regression model. Results: Of the 58 patients, the mean follow-up was 12.7±17.3 months (range: 2-83 months), and 14 patients (23.7%) had a prior history of TCC. During follow-up, 9 patients (15.3%) had TCC and 1 patient had prostate cancer. In the later TCC group, the incidence of a prior history of TCC (p=0.03) and persistent abnormal cytology (p<0.001) were higher than in the benign group in univariate analysis. In the Cox proportional hazards regression model, persistent abnormal cytology (p=0.033, relative risk (RR): 17.380 [95% CI: 1.265-238.783]) was the only independent factor to predict later TCC. The mean follow-up duration of later TCC demonstration was 8.55 months (range: 2-32 months). Conclusions: Our results suggest that in the setting of persistent abnormal urine cytology with a negative initial evaluation, 53.3% of patients will later develop TCC. Patients with persistent abnormal cytology need intensive follow-up within 1 year. (Korean J Urol 2009;50:125-129)
TL;DR: Serum IL-6 levels are a better indicator of the severity of disease and the therapeutic effect of empirical parenteral antibiotic use in patients with acute uncomplicated pyelonephritis than were either CRP or WBC counts.