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Ioanna Petta
Researcher at Ghent University
Publications - 13
Citations - 613
Ioanna Petta is an academic researcher from Ghent University. The author has contributed to research in topics: Glucocorticoid receptor & Inflammation. The author has an hindex of 10, co-authored 13 publications receiving 460 citations. Previous affiliations of Ioanna Petta include University of Hasselt & Transnational University Limburg.
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Journal ArticleDOI
The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases
Ioanna Petta,Lien Dejager,Marlies Ballegeer,Sam Lievens,Jan Tavernier,Karolien De Bosscher,Claude Libert +6 more
TL;DR: A state-of-the-art overview of the protein-protein interactions of GR that positively or negatively affect its anti-inflammatory properties, along with mechanistic insights, if known.
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Modulation of Protein–Protein Interactions for the Development of Novel Therapeutics
TL;DR: A focused overview of a number of PPIs that control critical regulatory pathways and constitute targets for the design of novel therapeutics that are still under preclinical investigation but for which preliminary data support their use as therapeutic targets are provided.
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Dominance of the strongest: Inflammatory cytokines versus glucocorticoids
Lien Dejager,Lien Dejager,Sofie Vandevyver,Sofie Vandevyver,Ioanna Petta,Ioanna Petta,Claude Libert,Claude Libert +7 more
TL;DR: New insights into the molecular mechanisms of GR-mediated actions and GCR are needed for the design of more effective GC-based therapies, because when cytokines overrule the anti-inflammatory actions of GCs, patients become GC insensitive.
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Tumor Necrosis Factor Inhibits Glucocorticoid Receptor Function in Mice A STRONG SIGNAL TOWARD LETHAL SHOCK
Tom Van Bogaert,Sofie Vandevyver,Lien Dejager,Filip Van Hauwermeiren,Iris Pinheiro,Ioanna Petta,David Engblom,Anna Kleyman,G. Schutz,Jan Tuckermann,Claude Libert +10 more
TL;DR: It is suggested that the decreased amount of GR determines the GR response and outcome of TNFα-induced shock, as supported by studies with GR heterozygous mice.
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LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome
Iris Pinheiro,Lien Dejager,Ioanna Petta,Sofie Vandevyver,Leen Puimège,Tina Mahieu,Marlies Ballegeer,Filip Van Hauwermeiren,Carlo Riccardi,Marnik Vuylsteke,Claude Libert +10 more
TL;DR: It is reported that LPS resistance of the inbred mouse strain SPRET/Ei, previously reported to depend on the glucocorticoid receptor (GR), maps to the distal region of the X‐chromosome and encoded by Tsc22d3, encoding the protein Gilz, and that it could become a treatment option for sepsis.