S
Sam Lievens
Researcher at Ghent University
Publications - 60
Citations - 1886
Sam Lievens is an academic researcher from Ghent University. The author has contributed to research in topics: Protein–protein interaction & Sesbania rostrata. The author has an hindex of 24, co-authored 60 publications receiving 1675 citations. Previous affiliations of Sam Lievens include Flanders Institute for Biotechnology.
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Journal ArticleDOI
The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases
Ioanna Petta,Lien Dejager,Marlies Ballegeer,Sam Lievens,Jan Tavernier,Karolien De Bosscher,Claude Libert +6 more
TL;DR: A state-of-the-art overview of the protein-protein interactions of GR that positively or negatively affect its anti-inflammatory properties, along with mechanistic insights, if known.
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Modulation of Protein–Protein Interactions for the Development of Novel Therapeutics
TL;DR: A focused overview of a number of PPIs that control critical regulatory pathways and constitute targets for the design of novel therapeutics that are still under preclinical investigation but for which preliminary data support their use as therapeutic targets are provided.
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Srchi13, a novel early nodulin from Sesbania rostrata, is related to acidic class III chitinases
TL;DR: The specific and transient transcript accumulation together with the lipochitooligosaccharide degradation activity of the recombinant protein hint at a role of Srchi13 in normal nodule ontogeny by limiting the action of Nod factors.
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The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Michal Simicek,Sam Lievens,Mathias Laga,Dmytro Guzenko,Vasily N. Aushev,Peter Kalev,Maria Francesca Baietti,Sergei V. Strelkov,Kris Gevaert,Jan Tavernier,Anna Sablina +10 more
TL;DR: Sablina et al. as mentioned in this paper found that whereas ubiquitylation of RALB at K47 promotes its interaction with SEC5, the de-ubiquitylase USP33 switches RALb to the EXO84-beclin complex to promote autophagy during nutrient starvation.
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A critical evaluation of differential display as a tool to identify genes involved in legume nodulation: looking back and looking forward.
TL;DR: The advantages with respect to tissue specificity of this particular model system for legume nodulation and the results of a screening for early nodulation-related genes have been considered in the context of transcriptome analyses in other rhizobium-legume interactions.