Iram Khan Iqbal

TL;DR: Inhibitors of oxidative phosphorylation can synergize with frontline TB drugs to shorten the course of treatment and play a critical role in the survival of persisters.

TL;DR: Reported strains capable of measuring the metabolic state of Mtb cells in vitro and in vivo with spatio-temporal resolution are generated and it is believed that this tool will facilitate further studies on mycobacterial physiology and will create new avenues of research for anti-tuberculosis drug discovery.

TL;DR: In this paper, hydrogen sulfide (H2S) sulfhydrates the active site cysteine of the glycolytic enzyme GAPDH (glyceraldehyde-3-phosphate dehydrogenase).

TL;DR: This chapter describes the details of a method used in the generation of reporter strains for the measurement of the NADH/NAD+ ratio in mycobacteria, and believes that such reporter stains can be used in novel screens for small molecules that could alter the metabolism of bacterial cells and thus aid in the development of new class of therapeutic agents.

TL;DR: In this article , a ternary complex modeling algorithm, ALMOND (ALgorithm for MOdeling Neo substrate Degraders) was used to identify structurally unique highly selective CBP/p300 degraders, which were further optimized for potency, selectivity and ADME properties.