I
Irina Kolesnikova
Researcher at Public Health Research Institute
Publications - 2
Citations - 531
Irina Kolesnikova is an academic researcher from Public Health Research Institute. The author has contributed to research in topics: Mutant & Mycobacterium tuberculosis. The author has an hindex of 2, co-authored 2 publications receiving 482 citations.
Papers
More filters
Journal ArticleDOI
The Mycobacterium tuberculosis PhoPR two‐component system regulates genes essential for virulence and complex lipid biosynthesis
TL;DR: Functional evidence is provided for the PhoPR 2‐CS involvement in Mtb pathogenesis and it is suggested that a major reason for the attenuation observed in the phoP mutant is the absence of certain complex lipids that are known to be important for virulence.
Journal ArticleDOI
A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.
Natasha M. Nesbitt,Xinxin Yang,Patricia A. Fontán,Patricia A. Fontán,Irina Kolesnikova,Issar Smith,Issar Smith,Nicole S. Sampson,Eugenie Dubnau,Eugenie Dubnau +9 more
TL;DR: It is demonstrated that FadA5 catalyzes the thiolysis of acetoacetyl-coenzyme A (CoA) and this catalytic activity is consistent with a β-ketoacyl-CoA thiolase function in cholesterol β-oxidation that is required for the production of androsterones.