F
Françoise Laval
Researcher at University of Toulouse
Publications - 52
Citations - 3414
Françoise Laval is an academic researcher from University of Toulouse. The author has contributed to research in topics: Mycobacterium tuberculosis & Mycobacterium smegmatis. The author has an hindex of 30, co-authored 52 publications receiving 3107 citations. Previous affiliations of Françoise Laval include Centre national de la recherche scientifique & Paul Sabatier University.
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Journal ArticleDOI
Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer
Timothy P. Stinear,Torsten Seemann,Sacha J. Pidot,Wafa Frigui,Gilles Reysset,Thierry Garnier,Guillaume Meurice,David Simon,Christiane Bouchier,Laurence Ma,Magali Tichit,Jessica L. Porter,Janine Ryan,Paul D R Johnson,John K. Davies,Grant A. Jenkin,Pamela L. C. Small,Louis Jones,Fredj Tekaia,Françoise Laval,Mamadou Daffé,Julian Parkhill,Stewart T. Cole +22 more
TL;DR: The complete 5.8-Mb genome sequence of M. ulcerans is reported and indicates that it has recently evolved via lateral gene transfer and reductive evolution from the generalist, more rapid-growing environmental species M. marinum to become a niche-adapted specialist.
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The Mycobacterium tuberculosis PhoPR two‐component system regulates genes essential for virulence and complex lipid biosynthesis
TL;DR: Functional evidence is provided for the PhoPR 2‐CS involvement in Mtb pathogenesis and it is suggested that a major reason for the attenuation observed in the phoP mutant is the absence of certain complex lipids that are known to be important for virulence.
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The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis.
Jesús Gonzalo Asensio,Catarina Maia,Nadia L. Ferrer,Nathalie Barilone,Françoise Laval,Carlos Y. Soto,Nathalie Winter,Mamadou Daffé,Brigitte Gicquel,Carlos Martin,Mary Jackson +10 more
TL;DR: The results indicate that PhoP coordinately and positively regulates the synthesis of methyl-branched fatty acid-containing acyltrehaloses known to be restricted to pathogenic species of the M. tuberculosis complex, namely diacylt rehaloses, polyacyltre Haloses, and sulfolipids.
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Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy
Lian-Yong Gao,Françoise Laval,Elise H. Lawson,Richard K. Groger,Andy Woodruff,J. Hiroshi Morisaki,Jeffery S. Cox,Mamadou Daffé,Eric J. Brown +8 more
TL;DR: The kasB mutants exhibited strikingly altered cell wall permeability, leading to a marked increase in susceptibility to lipophilic antibiotics and the host antimicrobial molecules defensin and lysozyme, and are identified as a novel target for therapeutic intervention in mycobacterial diseases.
Journal ArticleDOI
Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator
Jesús Gonzalo-Asensio,Wladimir Malaga,Alexandre Pawlik,Catherine Astarie-Dequeker,Catherine Astarie-Dequeker,Charlotte Passemar,Charlotte Passemar,Flavie Moreau,Flavie Moreau,Françoise Laval,Françoise Laval,Mamadou Daffé,Mamadou Daffé,Carlos Martin,Roland Brosch,Christophe Guilhot,Christophe Guilhot +16 more
TL;DR: It is shown by genetic transfer and virulence experiments that specific mutations in a virulence regulator contribute to lower fitness and virosity of M. bovis and related strains for the human host, likely obstructing the capacity of causing overt disease needed for efficient human-to-human transmission.