Iris Bischoff

TL;DR: The first direct comparison of these assays applied to one single cell type (human microvascular ECs) under the same experimental conditions concludes that the complementary combination of both approaches is highly recommended to overcome the restrictions of each assay.

TL;DR: Chemical diversity of the biologically active RXPs results from a combination of iterative and flexible use of monomodular nonribosomal peptide synthetases including substrate promiscuity, enzyme cross-talk and enzyme stoichiometry as shown by in vivo and in vitro experiments.

TL;DR: The results of this study raise the possibility of actively using pro-inflammatory stimuli in a tissue engineering context to accelerate healing mechanisms.

TL;DR: An in vitro coculture model consisting of outgrowth endothelial cells and primary osteoblasts is used and the role of “gap junctions,” small protein pores which connect adjacent cells, are investigated to investigate certain growth factors and cell communication molecules that are important during bone repair processes.

TL;DR: A causal link between ACC, membrane lipid composition, and cell migration in ECs is provided and ACC inhibition offers a new and valuable therapeutic perspective for the treatment of EC migration-related diseases.