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Irwin A. Rose
Researcher at University of California, Irvine
Publications - 76
Citations - 5758
Irwin A. Rose is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Ubiquitin & Aldolase A. The author has an hindex of 38, co-authored 76 publications receiving 5650 citations. Previous affiliations of Irwin A. Rose include University of Chicago.
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Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.
TL;DR: A sequence of reactions in which the linkage of APF-1 to the substrates is followed by the proteolytic breakdown of the substrate is proposed to explain the role of ATP.
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Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation.
TL;DR: Derivatization of the thiol site prevents conjugate formation in a reconstituted system, demonstrating that the ubiquitin thiolester is the proximal donor for subsequent conjugates formation.
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Mitochondrial hexokinase. Release, rebinding, and location.
Irwin A. Rose,Jessie V. B. Warms +1 more
TL;DR: The tumor mitochondrial hexokinase is not in the compartment of oxidative phosphorylation, as shown by kinetic competition studies for oxidatively generated adenosine triphosphate and the lack of effect of atractyloside on the action of Hexokinase on added ATP.
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The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis.
Arthur L. Haas,Irwin A. Rose +1 more
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Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown.
TL;DR: It is shown that the selective modification of NH2-terminal alpha-NH2 groups of globin and lysozyme prevents their degradation by the ubiquitin proteolytic system from reticulocytes.