Irwin M. Arias

TL;DR: The rate of disappearance of antipynine from plasma after oral administration of 600 mg of antipyrine was determined in 11 normal subjects, five chronically unemic patients on a hemodialysis program and eight nondialyzed chronically uremic patients and a quantitative gas-liquid chromatographic method for antipyrines determination was developed.

TL;DR: Results suggest that a sequence abnormality in the 3-MC-inducible UDPGT mRNA in Gunn rats results in reduced mRNA concentration and synthesis of a truncated, enzymically inactive UDPGT.

TL;DR: Although patients with the Crigler-Najjar syndrome and Gunn rats lack UDP glucuronate glucuronyltransferase, their livers enzymatically convert bilirubin monoglucuronid to diglucuronide in vitro, demonstrated in Gunn rats in vivo.

TL;DR: Functional, cytochemical, and ultrastructural studies showed a remarkable return to normal patterns in a 27-year-old Caucasian man who had experienced 14 episodes of pruritus, jaundice, bilirubinuria, and weight loss since puberty, spontaneously on each occasion.

TL;DR: Observations indicate that, although ligand-protein interaction in the circulation is important for directing bilirubin to the plasma membranes of the hepatocyte, this mechanism is not specific for albumin.