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Isabella Irrcher
Researcher at Queen's University
Publications - 29
Citations - 2784
Isabella Irrcher is an academic researcher from Queen's University. The author has contributed to research in topics: Mitochondrial biogenesis & Mitochondrion. The author has an hindex of 20, co-authored 29 publications receiving 2538 citations. Previous affiliations of Isabella Irrcher include York University & University of Iowa.
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Journal ArticleDOI
Coordination of metabolic plasticity in skeletal muscle.
TL;DR: In this paper, the authors studied the effect of contractile activity on the expression and activation of a variety of nuclear DNA and mitochondrial DNA (mtDNA) gene products, leading to phenotypic adaptations.
Journal ArticleDOI
Loss of the Parkinson’s Disease-linked gene DJ-1 perturbs mitochondrial dynamics
Isabella Irrcher,Hossein Aleyasin,Erin L. Seifert,Sarah Hewitt,S. Chhabra,Maryam Phillips,Anne Kathrin Lutz,Maxime W.C. Rousseaux,Lisa Bevilacqua,Arezu Jahani-Asl,Steven M. Callaghan,Jason G. MacLaurin,Konstanze F. Winklhofer,Patrizia Rizzu,Peter Rippstein,Raymond H. Kim,Carol X.-Q. Chen,Edward A. Fon,Ruth S. Slack,Mary-Ellen Harper,Heidi M. McBride,Tak W. Mak,David S. Park +22 more
TL;DR: A mechanism by which the DJ-1-dependent mitochondrial defects contribute to the increased sensitivity to oxidative stress-induced cell death that has been previously reported is defined.
Journal ArticleDOI
PPARγ coactivator-1α expression during thyroid hormone-and contractile activity-induced mitochondrial adaptations
TL;DR: The transcriptional coactivator the peroxisome proliferator-activated receptor γ coActivator-1α (PGC-1 α) has been identified as an important mediator of mitochondrial biogenesis based on its role in transcriptional regulation and cell reprograming.
Journal ArticleDOI
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.
L Bouman,Anita Schlierf,Anne Kathrin Lutz,J Shan,A Deinlein,Juergen Kast,Zohreh Galehdar,V Palmisano,N Patenge,Daniela Berg,Thomas Gasser,R Augustin,Dietrich Trümbach,Isabella Irrcher,David S. Park,David S. Park,Wolfgang Wurst,Michael S. Kilberg,Jörg Tatzelt,Konstanze F. Winklhofer +19 more
TL;DR: The study supports the notion that parkin has a role in the interorganellar crosstalk between the ER and mitochondria to promote cell survival under stress, suggesting that both ER and mitochondrial stress can contribute to the pathogenesis of Parkinson's disease.
Journal ArticleDOI
Regulation of Mitochondrial Biogenesis in Muscle by Endurance Exercise
TL;DR: The importance and relevance of chronic physical activity in the induction of mitochondrial biogenesis is considered, with particular emphasis on how an endurance training programme could positively affect the age-related decline in mitochondrial content and delay the progression of age- and physical inactivity-related diseases.