Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

/pdf/chalcone-a-privileged-structure-in-medicinal-chemistry-2glhtivnj7.pdf

Chalcone: A Privileged Structure in Medicinal Chemistry.

2,5-Diketopiperazines: synthesis, reactions, medicinal chemistry, and bioactive natural products.

Cell host & microbe

https://www.embl-hamburg.de/biosaxs/reprints/flexible_disordered_2015.pdf

A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins

Drug discovery utilizes chemical biology and computational drug design approaches for the efficient identification and optimization of lead compounds. Chemical biology is mostly involved in the elucidation of the biological function of a target and the mechanism of action of a chemical modulator. On the other hand, computer-aided drug design makes use of the structural knowledge of either the target (structure-based) or known ligands with bioactivity (ligand-based) to facilitate the determination of promising candidate drugs. Various virtual screening techniques are now being used by both pharmaceutical companies and academic research groups to reduce the cost and time required for the discovery of a potent drug. Despite the rapid advances in these methods, continuous improvements are critical for future drug discovery tools. Advantages presented by structure-based and ligand-based drug design suggest that their complementary use, as well as their integration with experimental routines, has a powerful impact on rational drug design. In this article, we give an overview of the current computational drug design and their application in integrated rational drug development to aid in the progress of drug discovery research.

https://link.springer.com/content/pdf/10.1007%2Fs12272-015-0640-5.pdf

Role of computer-aided drug design in modern drug discovery

L'invention a pour objet de nouveaux peptides isoles, purifies, possedant notamment des proprietes de liaison a la proteine Nef, caracterises en ce qu'ils renferment une sequence en acides amines repondant a SEQ ID N°1 : W-P-a-W-L-P dans laquelle a est choisi parmi W, A, S ou D.

Nouveaux peptides et leurs applications biologiques

An improvement of the 1,2,5-oxadiazine-3,6-diones (Oxd) synthesis and reactivity is described in this paper. The methodology has been successfully applied to produce a library of this poorly studied scaffold, which can be considered as an oxa-diketopiperazine (oxa-DKP). Significantly, the first crystal structures of oxa-DKP were obtained and compared to the diketopiperazine ring. Finally, a straightforward procedure concerning the coupling of various amino acids with oxa-DKP heterocycles to afford original peptidomimetics was reported. The conformational analysis realized on di- and tripeptide analogs revealed that the oxa-DKP skeleton exhibited remarkable β-turn inducer properties.

Oxa–diketopiperazines: Access and Conformational Analysis of Potential Turn Inducers

The subject of the invention is peptides having, in particular, binding properties to the Nef protein, characterized in that they contain an amino acid sequence corresponding to SEQ ID No. 1 .WPaWL-P in which is selected from W, A, S or D.

Novel peptides and their biological applications

Profumi

L'invention a pour objet de nouveaux peptides isoles, purifies, possedant notamment des proprietes de liaison a la proteine Nef, caracterises en ce qu'ils renferment une sequence en acides amines repondant a SEQ ID N°1 : W-P-a-W-L-P dans laquelle a est choisi parmi W, A, S ou D

Isabelle Parrot

Papers

Nouveaux peptides et leurs applications biologiques

Oxa–diketopiperazines: Access and Conformational Analysis of Potential Turn Inducers

Novel peptides and their biological applications

Profumi

Peptides qui peuvent se lier a la proteine nef et leurs applications pharmaceutiques