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Isabelle Tillie-Leblond
Researcher at university of lille
Publications - 122
Citations - 5987
Isabelle Tillie-Leblond is an academic researcher from university of lille. The author has contributed to research in topics: Asthma & Inflammation. The author has an hindex of 38, co-authored 122 publications receiving 5611 citations. Previous affiliations of Isabelle Tillie-Leblond include French Institute of Health and Medical Research & Lille University of Science and Technology.
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Journal ArticleDOI
Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity
Vincent Cottin,Hilario Nunes,Philippe Delaval,Gilles Devouassoux,Isabelle Tillie-Leblond,Dominique Israel-Biet,Isabelle Court-Fortune,Dominique Valeyre +7 more
TL;DR: The authors individualise the computer tomography-defined syndrome of combined pulmonary fibrosis and emphysema characterised by subnormal spirometry, severe impairment of gas exchange, high prevalence of pulmonary hypertension, and poor survival.
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Bronchial Neutrophilia in Patients with Noninfectious Status Asthmaticus
C. Lamblin,Philippe Gosset,Isabelle Tillie-Leblond,Fabienne Saulnier,Charles-Hugo Marquette,Benoit Wallaert,André-Bernard Tonnel +6 more
TL;DR: Investigation of the contribution of different cell types and cellular mediators to the pathogenesis of status asthmaticus indicates that bronchial inflammation in SA differs from bronchia inflammation in mild asthma, and persistentBronchial neutrophilia is associated with increased eosinophils and mast cells in the early phase of SA.
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Clinical COPD phenotypes: a novel approach using principal component and cluster analyses
Pierre-Régis Burgel,Jean-Louis Paillasseur,Denis Caillaud,Isabelle Tillie-Leblond,P. Chanez,Roger Escamilla,Isabelle Court-Fortune,Tamara Alonso Pérez,Philippe Carré,Nicolas Roche +9 more
TL;DR: Importantly, subjects with comparable airflow limitation (FEV1) belonged to different phenotypes and had marked differences in age, symptoms, comorbidities and predicted mortality, underscore the need for novel multidimensional COPD classification for improving patient care and quality of clinical trials.
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Pulmonary Embolism in Patients with Unexplained Exacerbation of Chronic Obstructive Pulmonary Disease: Prevalence and Risk Factors
Isabelle Tillie-Leblond,Charles-Hugo Marquette,Thierry Perez,Arnaud Scherpereel,Christophe Zanetti,André-Bernard Tonnel,Martine Remy-Jardin +6 more
TL;DR: This study prospectively evaluated PE in patients with COPD exacerbation of unknown origin and examined factors associated with the presence of PE, including the Geneva score, in a single-center study.
Journal ArticleDOI
Balance between Proinflammatory Cytokines and Their Inhibitors in Bronchial Lavage from Patients with Status Asthmaticus
Isabelle Tillie-Leblond,Jérôme Pugin,Charles-Hugo Marquette,C. Lamblin,Fabienne Saulnier,A Brichet,Benoit Wallaert,André-Bernard Tonnel,Philippe Gosset +8 more
TL;DR: Despite a marked increase of anti-inflammatory mediators in BL from patients with SA, the net inflammatory activity was found to be proinflammatory and mainly due to the presence of bioactive IL-1beta and to a lesser extent TNF-alpha.