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Isha Sharma

Researcher at Northwestern University

Publications -  20
Citations -  373

Isha Sharma is an academic researcher from Northwestern University. The author has contributed to research in topics: Inositol oxygenase & Granulosa cell. The author has an hindex of 8, co-authored 20 publications receiving 211 citations. Previous affiliations of Isha Sharma include National Dairy Research Institute & Centre for Cellular and Molecular Biology.

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Journal ArticleDOI

Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule

Fei Deng, +5 more
- 01 Nov 2019 - 
TL;DR: Findings indicate that ferroptosis, an integral process in the pathogenesis of Cisplatin-induced AKI, is modulated by the expression profile of MIOX.
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Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI

Rajesh Kumar Dutta, +5 more
- 01 May 2017 - 
TL;DR: MIOX overexpression exacerbates, whereas MIOX gene disruption protects against, cisplatin-induced AKI, according to analysis of genomic DNA in WT mice.
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Characterization of serum-free buffalo granulosa cell culture and analysis of genes involved in terminal differentiation from FSH- to LH-responsive phenotype

Rachna Monga, +3 more
- 01 Nov 2011 - 
TL;DR: Gen expression and hormone analysis showed that buffalo granulosa cells exhibit FSH responsiveness with preovulatory phenotype having highest CYP19 gene expression and 17β-estradiol production, whereas a significant increase in transcript abundance of STAR, CYP11, and HSD3B genes accompanied with an increase in progesterone production was observed on day 8.
Journal ArticleDOI

Contribution of myo-inositol oxygenase in AGE:RAGE-mediated renal tubulointerstitial injury in the context of diabetic nephropathy

Isha Sharma, +3 more
- 01 Jan 2018 - 
TL;DR: A role of AGE:RAGE interaction in the activation of PI3K-AKT pathway and upregulation of MIOX, with excessive generation of ROS, increased expression of NF-κB, inflammatory cytokines, TGF-β, and fibronectin is supported.
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Conjugated linoleic acids attenuate FSH- and IGF1-stimulated cell proliferation; IGF1, GATA4, and aromatase expression; and estradiol-17β production in buffalo granulosa cells involving PPARγ, PTEN, and PI3K/Akt

Isha Sharma, +1 more
- 01 Sep 2012 - 
TL;DR: This study demonstrated the cross talk between downstream signaling of CLA and important hormone regulators of endocrine system, i.e. FSH and IGF1, on buffalo granulosa cell function (proliferation and steroidogenesis) and found that CLA intervenes the IGF1 signaling by decreasing p-Akt.