Showing papers by "Itzhak Brook published in 1990"
TL;DR: The predominance of certain isolates in certain anatomical sites was correlated with their distribution in the normal flora adjacent to the infected site, highlighting the polymicrobial nature of wounds and cutaneous abscesses.
Abstract: • The aerobic and anaerobic microbiologic characteristics of 584 wounds and 676 skin or soft-tissue abscesses were studied and correlated with the infection site. In wounds, aerobic or facultative bacteria only were present in 223 specimens (38%), anaerobes only in 177 specimens (30%), and mixed flora in 184 specimens (32%). In total there were 1470 isolates, 558 aerobic and 912 anaerobic, an average of 2.5 isolates per wound (1.6 anaerobic and 0.9 aerobic isolates). In abscesses, aerobic or facultative bacteria were recovered in 177 specimens (26%), anaerobes only in 243 specimens (36%), and mixed flora in 256 specimens (38%). In total there were 1702 isolates, 602 aerobic and 1100 anaerobic, an average of 2.5 isolates per abscess. The highest rates of anaerobes in wounds were in the inguinal, buttocks, and trunk areas and in abscesses in the perirectal, external genitalia, neck, and inguinal areas. The predominant aerobic organisms wereStaphylococcus aureus(363 isolates), group A streptococci (98 isolates), andEscherichia coli(97 isolates). The predominant anaerobic organisms were Bacteroides species (986 isolates),Peptostreptococcusspecies (559 isolates), Clostridium species (153 isolates), and Fusobacterium species (109 isolates). The predominance of certain isolates in certain anatomical sites was correlated with their distribution in the normal flora adjacent to the infected site. These data highlight the polymicrobial nature of wounds and cutaneous abscesses. (Arch Surg. 1990;125:1445-1451)
87 citations
TL;DR: It is concluded that beta-lactamase production by normal pharyngeal flora does not fully explain the failure of penicillin therapy for acute streptococcal pharyngitis and using an antibiotic effective against beta- lactam enzyme-producing bacteria will not eliminate the problem of bacteriologic treatment failure.
52 citations
TL;DR: The data illustrate the presence of polymicrobial flora in the cores of normal noninflamed tonsils and the increase in their number and encapsulation during the inflammatory process.
Abstract: Core tonsillar cultures for aerobic and anaerobic bacteria were performed on four normal tonsils removed from four children because of velopharyngeal insufficiency and on four tonsils removed from four children because of recurrent tonsillitis. The data illustrate the presence of polymicrobial flora in the cores of normal noninflamed tonsils and the increase in their number and encapsulation during the inflammatory process.
45 citations
7 citations
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Journal Article•
TL;DR: Findings support the earlier observation in which aerobic and anaerobic bacteria in uninfected maxillary sinuses were recovered, and the colonization of the sinus cavity with oral flora may explain the chain of events that lead to infection.
Abstract: In Reply.— In our opinion, the nonsterility of the normal maxillary sinuses has not been resolved completely, in part because of the obvious difficulties in performing maxillary sinus punctures in healthy individuals. We have recovered high titers of bacteria in sinus aspirates of 28.6% of our patients with normal maxillary sinus x-rays. However, all the children in our study had chronic tonsillitis and/or adenoids enlargement, and therefore our results only apply to children with those underlying conditions.
2 citations