Ivan I. Galkin

TL;DR: Data indicate that mtROS play a critical role in signal transduction that mediates the major neutrophil functional responses in the process of activation, and is implicated in the oxidative burst caused by NOX2 activation as well as in the exocytosis of primary and secondary granules.

TL;DR: The data indicate an important role of mitochondrial reactive oxygen species in regulation of the NF-κB pathway and corresponding age-related inflammatory activation of endothelium.

TL;DR: It is shown that both sources of ROS, mitochondria and NADPH oxidase, are involved in NETosis induced by A23187 in human neutrophils and the mPTP is involved in mtROS production, NETosis, and the oxidative burst induced by a23187.

TL;DR: In vitro mild uncoupling rescued from TNF-induced endothelial permeability, disassembly of cell contacts and VE-cadherin cleavage by the matrix metalloprotease 9, suggesting that the protective action of the uncouplers is linked to their antioxidant potential.

TL;DR: The data indicate a causative role of mitochondrial reactive oxygen species in cardiovascular aging and imply that SkQ1 has potential as a drug against age-related cardiac dysfunction.