Ivan Petersen

TL;DR: In this article, it is becoming increasingly evident that impaired solubilization of immune complexes in patients with compromised complement (C) function may permit the complexes to deviate from their normal pattern of interaction with C3 receptors probably influencing both the organ distribution and clearance of IC and thereby also their phlogistic potentials.

TL;DR: Reduced complement-mediated solubilization (CMS) of pre-formed immune complexes (IC) was demonstrated in sera from 11 out of 12 SLE patients and sera of 14 rheumatoid arthritis patients exhibited normal CMS.

TL;DR: Preliminary investigation of pathological sera showed that both IKS and CMSC were clearly reduced in SLE sera and by contrast, rheumatoid arthritis sera exhibited normal I KS and only marginal reduction in CMSC.

TL;DR: Nine patients with active classical rheumatoid arthritis were studied with reference to circadian variation of immunological and clinical parameters, andplement-mediated solubilization of immune complexes and the level of circulating IC were found to be inversely related with low CMS and increased IC levels in the morning, and vice versa in the afternoon.

TL;DR: Serum samples from 19 SLE patients showed reduced capacity to mediate complement-dependent solubilization of immune complexes (IC) and the strongest CMSC inhibition was exerted by sera from newly discovered cases of SLE who received no medical treatment and the lowest inhibition bysera from patients with inactive disease.