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Ivano Mezzaroma
Researcher at Sapienza University of Rome
Publications - 130
Citations - 2902
Ivano Mezzaroma is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Viral load & T cell. The author has an hindex of 28, co-authored 122 publications receiving 2550 citations.
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Journal ArticleDOI
A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia.
Isabella Quinti,Vassilios Lougaris,Cinzia Milito,Francesco Cinetto,Antonio Pecoraro,Ivano Mezzaroma,Claudio Maria Mastroianni,Ombretta Turriziani,Maria Pia Bondioni,Matteo Filippini,Annarosa Soresina,Giuseppe Spadaro,Carlo Agostini,Rita Carsetti,Alessandro Plebani +14 more
TL;DR: In this paper, COVID-19 had a mild clinical course in patients with Agammaglobulinemia lacking B lymphocytes, whereas it developed aggressively in Common Variable Immune Deficiency.
Journal Article
Failure to reconstitute CD4+ T-cells despite suppression of HIV replication under HAART.
Fernando Aiuti,Ivano Mezzaroma +1 more
TL;DR: There may be little rationale for using immunosuppressive agents such as cyclosporine or hydroxyurea in this subgroup of immunologic nonresponder patients, as these molecules may increase T-cell decline and/or favor susceptibility to infections.
Journal ArticleDOI
Long-term evaluation of T-cell subsets and T-cell function after HAART in advanced stage HIV-1 disease.
Ivano Mezzaroma,M. Carlesimo,Elena Pinter,Cecilia Alario,Giovanna Sacco,Donatella Santini Muratori,Maria Livia Bernardi,Roberto Paganelli,Fernando Aiuti +8 more
TL;DR: The immune recovery observed is slower and not complete in severely immunocompromised patients and the data suggest that HAART may be continued also in the absence of a significant HIV RNA decrease if alternative drugs are not available.
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T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART.
Marco Marziali,Wladimiro De Santis,Rossella Carello,Wilma Leti,Antonella Esposito,Antonella Isgrò,Caterina Fimiani,Maria Caterina Sirianni,Ivano Mezzaroma,Fernando Aiuti +9 more
TL;DR: The reduced expression of IL-7Rα associated with the persistent immune activation and the alteration of Treg frequencies in part explains the low level of CD4 T cells observed in InR.
Journal ArticleDOI
Human infection with Cryptosporidium felis: case report and literature review.
TL;DR: An infection with Cryptosporidium felis in an HIV-positive man from Italy was successfully treated with paromomycin, despite the patient's having a CD4+ cell count of 31/mL.