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Iza Wolinska
Researcher at University of Münster
Publications - 3
Citations - 1081
Iza Wolinska is an academic researcher from University of Münster. The author has contributed to research in topics: Phosphorylation & Apoptosis. The author has an hindex of 3, co-authored 3 publications receiving 1022 citations.
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HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
Jerzy Roch Nofer,Markus van der Giet,Markus Tölle,Iza Wolinska,Karin von Wnuck Lipinski,Hideo A. Baba,Uwe J. F. Tietge,Axel Gödecke,Isao Ishii,Burkhard Kleuser,Michael Schäfers,Manfred Fobker,Walter Zidek,Gerd Assmann,Jerold Chun,Bodo Levkau,Bodo Levkau +16 more
TL;DR: HDL is identified as a carrier of bioactive lysophospholipids that regulate vascular tone via S1P3-mediated NO release and induces vasodilation in isolated aortae via intracellular Ca2+ mobilization and Akt-mediated eNOS phosphorylation.
Journal ArticleDOI
Suppression of Endothelial Cell Apoptosis by High Density Lipoproteins (HDL) and HDL-associated Lysosphingolipids
Jerzy-Roch Nofer,Bodo Levkau,Iza Wolinska,Ralf Junker,Manfred Fobker,Arnold von Eckardstein,Udo Seedorf,Gerd Assmann +7 more
TL;DR: High density lipoproteins (HDL), a major anti-atherogenic lipoprotein fraction, protect endothelial cells against growth factor deprivation-induced apoptosis and is identified as a carrier of endogenous endothelial survival factors and suggests that inhibition of endothelial apoptosis by HDL-associated lysosphingolipids may represent an important and novel aspect of the anti- Atherogenic activity of HDL.
Journal ArticleDOI
Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux.
Nofer,Manfred Fobker,G. Hobbel,Reinhard Voss,Iza Wolinska,Martin Tepel,Walter Zidek,Ralf Junker,Udo Seedorf,von Eckardstein A,Gerd Assmann,Michael Walter +11 more
TL;DR: In fibroblasts from patients with Tangier disease which are characterized by defective cholesterol efflux, neither HDL-induced PtdInsP(2) breakdown and Ca(2+) mobilization nor cell proliferation was impaired, and two agonist activities are carried by HDL.