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Isao Ishii
Researcher at Showa Pharmaceutical University
Publications - 91
Citations - 7135
Isao Ishii is an academic researcher from Showa Pharmaceutical University. The author has contributed to research in topics: Receptor & Cystathionine beta synthase. The author has an hindex of 36, co-authored 80 publications receiving 6469 citations. Previous affiliations of Isao Ishii include University of California, San Diego & Keio University.
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Journal ArticleDOI
Lysophospholipid receptors: Signaling and biology
TL;DR: Generation of LP receptor-null animals has allowed rigorous examination of receptor-mediated physiological functions in vivo and has identified new functions for LP receptor signaling, and efforts to develop LP receptor subtype-specific agonists/antagonists are in progress.
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HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
Jerzy Roch Nofer,Markus van der Giet,Markus Tölle,Iza Wolinska,Karin von Wnuck Lipinski,Hideo A. Baba,Uwe J. F. Tietge,Axel Gödecke,Isao Ishii,Burkhard Kleuser,Michael Schäfers,Manfred Fobker,Walter Zidek,Gerd Assmann,Jerold Chun,Bodo Levkau,Bodo Levkau +16 more
TL;DR: HDL is identified as a carrier of bioactive lysophospholipids that regulate vascular tone via S1P3-mediated NO release and induces vasodilation in isolated aortae via intracellular Ca2+ mobilization and Akt-mediated eNOS phosphorylation.
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Lysophosphatidic acid receptors.
TL;DR: Current knowledge on high-affinity LPA receptors is reviewed, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.
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Sphingosine kinase type 2 is a putative BH3-Only protein that induces apoptosis
Hong Liu,Rachelle E. Toman,Rachelle E. Toman,Sravan K. Goparaju,Michael Maceyka,Victor E. Nava,Heidi Sankala,Shawn G. Payne,Meryem Bektas,Isao Ishii,Jerold Chun,Sheldon Milstien,Sarah Spiegel +12 more
TL;DR: SphK2 enhanced apoptosis in diverse cell types and also suppressed cellular proliferation, and the apoptotic effect of SphK2 might be because of its putative BH3 domain.
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Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice : signaling deficits without obvious phenotypic abnormality attributable to lpa(2)
James J. A. Contos,Isao Ishii,Nobuyuki Fukushima,Nobuyuki Fukushima,Marcy A. Kingsbury,Xiaoqin Ye,Shuji Kawamura,Joan Heller Brown,Jerold Chun +8 more
TL;DR: It is shown that deletion of lpa(2) in mice results in craniofacial dysmorphism, semilethality due to defective suckling behavior, and generation of a small fraction of pups with frontal hematoma, and it does act redundantly with LPA(1) to mediate most LPA responses in fibroblasts.