Hydrodynamics of Stirred Bioreactors

https://ris.utwente.nl/ws/files/6739600/Beenackers93mass.pdf

Mass transfer in gas-liquid slurry reactors

Multiple-impeller systems with a special emphasis on bioreactors: a critical review.

A five-compartment model for the liquid flow and the oxygen transfer into the liquid phase of a large-scale bioreactor is presented The aim of the model is to predict the following reactor operating variables: 1) the overall oxygen transfer capacity of the reactor; 2) the local liquid dissolved oxygen concentrations, for estimation of bad aerated zones which can introduce negative effects for the microorganisms and as a base for reliable scaledown experiments to estimate those effects; 3) the gas-phase exhaustion

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.260260522

Dissolved oxygen concentration profiles in a production-scale bioreactor.

Gas–liquid flow generated by a Rushton turbine in stirred vessel: CARPT/CT measurements and CFD simulations

Description de l'equipement utilise pour cette etude. Resultats experimentaux et revue des correlations predisant la vitesse de l'agitateur pour laquelle les particules sont juste en suspension dans un liquide non aere

Particle-gas-liquid mixing in stirred vessels. I: Particle-liquid mixing

Gas recirculation rate through impeller cavities and surface aeration in sparged agitated vessels

In a recent publication, a technique was outlined for measuring surface aeration rates in an agitated vessels while sparging, and it was shown that surface aeration rates fall rapidly with increasing sparge rates. That work was conducted in a 0.61 m diam vessels. The work reported here was done in a small vessel (0.22 m diam) where surface aeration has been reported to be of particular significance. In general, the results obtained in the small vessel confirmed those in the large one and in addition were generally in good agreement with those recently published elsewhere for an almost identical geometry. For typical practical power inputs and sparge rates, the rate of surface aeration was never more than 20% of the sparge rate and generally less than 5%. These results indicate that surface aeration is of considerably less importance than has generally been believed following the findings of workers who estimated its effect by comparing KLa values under unsparged conditions with those when sparging.

J. C. Middleton

Papers

Particle-gas-liquid mixing in stirred vessels. I: Particle-liquid mixing

Gas recirculation rate through impeller cavities and surface aeration in sparged agitated vessels

Surface aeration in a small, agitated, and sparged vessel