J
J. C. Parke
Researcher at Memorial Hospital of South Bend
Publications - 15
Citations - 966
J. C. Parke is an academic researcher from Memorial Hospital of South Bend. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 12, co-authored 15 publications receiving 959 citations.
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Journal ArticleDOI
Quantitative measurement of "natural" and immunization-induced Haemophilus influenzae type b capsular polysaccharide antibodies.
TL;DR: The “protective” level of serum anti-type b antibodies, estimated by two methods, was achieved by immunization of infants, which suggests that this procedure may confer protective immunity.
Journal ArticleDOI
Quantitative and qualitative analyses of serum antibodies elicited in adults by Haemophilus influenzae type b and pneumococcus type 6A capsular polysaccharide-tetanus toxoid conjugates
R Schneerson,JohnB Robbins,J. C. Parke,C. Bell,J. J. Schlesselman,Ann Sutton,Zhen Wang,Gerald Schiffman,Arthur B. Karpas,Joseph Shiloach +9 more
TL;DR: Conjugate-induced antibodies to both the polysaccharide and TT exerted biological activities that have been correlated with immunity and encourage the evaluation of Hib and Pn6A conjugates in human children and infants.
Journal Article
Immunity to disease caused by Hemophilus influenzae type b. II. Specificity and some biologic characteristics of "natural," infection-acquired, and immunization-induced antibodies to the capsular polysaccharide of Hemophilus influenzae type b.
TL;DR: Evidence for the protective quality of anti-type b antibodies was derived from the finding of an inverse relationship between the age incidence of influenzal meningitis and the percentage of individuals of different ages with serum anti-capsular antibodies.
Journal Article
An Escherichia coli antigen cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b: occurrence among known serotypes, and immunochemical and biologic properties of E. coli antisera toward H. influenzae type b.
Rachel Schneerson,Major Bradshaw,John K. Whisnant,Richard L. Myerowitz,J. C. Parke,John B. Robbins +5 more
TL;DR: An Escherichia coli antigen was shown to be cross-reactive with the capsular polysaccharide of Hemophilus influenzae type b and had “protective” activity against H. influenza type b in biologic assays.
Journal ArticleDOI
Clinical and immunologic responses to Haemophilus influenzae type b-tetanus toxoid conjugate vaccine in infants injected at 3, 5, 7, and 18 months of age
J. C. Parke,Rachel Schneerson,Charles B. Reimer,Charlotte M. Black,Sandy Welfare,Dolores A. Bryla,Lily Levi,Danka Pavliakova,Tod Cramton,Dominique Schulz,Michel Cadoz,John B. Robbins +11 more
TL;DR: Hib-TT, injected at 3, 5, 7, and 18 months, is safe and induces protective levels of antibodies during the age of highest incidence of meningitis caused by Hib, and elicited increases of Hib antibody in all isotypes.