J
J. Du Bois
Researcher at Stanford University
Publications - 141
Citations - 8527
J. Du Bois is an academic researcher from Stanford University. The author has contributed to research in topics: Catalysis & Amination. The author has an hindex of 45, co-authored 131 publications receiving 7720 citations. Previous affiliations of J. Du Bois include California Institute of Technology & Amgen.
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Journal ArticleDOI
Metal-catalyzed nitrogen-atom transfer methods for the oxidation of aliphatic C-H bonds.
TL;DR: The body of experimental and computational data is consistent with a concerted asynchronous C-H insertion pathway, analogous to the consensus mechanism for Rh-carbene transfer, which constitutes an important step toward the ultimate goal of achieving predictable, reagent-level control over product selectivity.
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Expanding the scope of C-H amination through catalyst design.
TL;DR: Analysis of the mechanism for Rh-mediated C-H amination has led to the development of a remarkably effective dinuclear Rh catalyst derived from 1,3-benzenedipropionic acid, which is superior to Rh2(O2CtBu)4.
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Synthesis of 1,3-Difunctionalized Amine Derivatives through Selective C−H Bond Oxidation
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A Rh‐Catalyzed C−H Insertion Reaction for the Oxidative Conversion of Carbamates to Oxazolidinones
Christine G. Espino,J. Du Bois +1 more
TL;DR: The reaction is stereospecific, providing access to chiral α-branched amines from optically pure starting materials with no loss in enantiomeric excess.
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Catalytic intermolecular amination of C-H bonds: method development and mechanistic insights.
TL;DR: In this article, a reaction methodology for intermolecular C−H amination of benzylic and 3°C−H bonds is described, which uses the starting alkane as the limiting reagent, gives optically pure tetrasubstituted amines through stereospecific insertion into enantiomeric 3° centers, displays high chemoselectivity for benzyric oxidation, and enables the facile preparation of isotopically enriched 15N-labeled compounds.