J
J. Goossens
Researcher at Janssen Pharmaceutica
Publications - 23
Citations - 1815
J. Goossens is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Antibody & Peripheral blood mononuclear cell. The author has an hindex of 17, co-authored 23 publications receiving 1801 citations.
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Journal Article
OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.
TL;DR: The cell membrane determinant recognized by OKT3 could be described as a "T cell stimulation receptor" as this interaction can trigger mitogenesis, the mitogenecity of the lymphocytes is not solely dependent on cross-linking of these receptors.
Journal Article
Effects of cytochrome P-450 inhibitors on the in vivo metabolism of all-trans-retinoic acid in rats.
TL;DR: In vivo inhibition of the P-450 pathway not only increased the biological half-life of exogenously administered RA, but also enhanced the endogenous plasma level of this vitamin A derivative.
Journal Article
Suppression of human T-cell mitogenesis and E-rosette formation by the monoclonal antibody OKT11A
TL;DR: Findings show that OKT11A recognizes a sparsely represented T-cell surface determinant that is associated with the inhibition of mitogenic responsiveness and E-rosette formation, and imply that the E- rosette receptor of T cells is involved in the regulation of immune functions.
Journal Article
Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo.
J. Van Wauwe,G. Van Nyen,M.-C. Coene,P. Stoppie,W. Cools,J. Goossens,P. Borghgraef,P. A. J. Janssen +7 more
TL;DR: Findings indicate that liarozole, an inhibitor of RA metabolism and RA produce similar morphologic and biochemical effects on the differentiation process of rat vaginal epithelium.
Journal Article
R115866 Inhibits All-trans-Retinoic Acid Metabolism and Exerts Retinoidal Effects in Rodents
P. Stoppie,M. Borgers,P. Borghgraef,Lieve Dillen,J. Goossens,Gerard Charles Sanz,H Szel,C. Van Hove,G. Van Nyen,G Nobels,H. F. A. Vanden Bossche,M. Venet,G. Willemsens,J. Van Wauwe +13 more
TL;DR: The data characterize R115866 as a potent, orally active inhibitor of RA metabolism, capable of enhancing RA levels and displaying retinoidal actions, supporting the idea that the actions of R 115866 result from increased availability of endogenous RA and improved RAR triggering.