J
J. Howard Parish
Researcher at University of Leeds
Publications - 3
Citations - 553
J. Howard Parish is an academic researcher from University of Leeds. The author has contributed to research in topics: Structural motif & Bacterial outer membrane. The author has an hindex of 3, co-authored 3 publications receiving 529 citations.
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Journal ArticleDOI
Photoinactivation of bacteria. Use of a cationic water-soluble zinc phthalocyanine to photoinactivate both gram-negative and gram-positive bacteria.
Andrew Minnock,David I. Vernon,Jack Schofield,John Griffiths,J. Howard Parish,Stanley B. Brown +5 more
TL;DR: Analysis of the cell killing curves and results suggest that cationic photosensitizers may have a broader application in the photoinactivation of bacterial cells than the anionic or neutral photosensitiveers commonly used in photodynamic therapy.
Journal ArticleDOI
Mechanism of uptake of a cationic water-soluble pyridinium zinc phthalocyanine across the outer membrane of Escherichia coli.
Andrew Minnock,David I. Vernon,Jack Schofield,John Griffiths,J. Howard Parish,Stanley B. Brown +5 more
TL;DR: Results are consistent with the hypothesis that PPC gains access across the outer membrane of E. coli cells via the self-promoted uptake pathway, a mechanism of uptake postulated for the uptake of other cationic compounds across theouter membranes of gram-negative bacteria.
Journal ArticleDOI
Key residues approach to the definition of protein families and analysis of sparse family signatures.
Jon Ison,Matthew J. Blades,Alan J. Bleasby,Stephen C. Daniel,J. Howard Parish,John B. C. Findlay +5 more
TL;DR: The concept of the motif as a tool for characterizing protein families is extended and the feasibility of a sparse “motif” that is the length of the protein sequence itself is explored, resulting in a sparse family signature consisting of a set of N key residue positions preceded by gaps.