J
J. I. Mason
Researcher at University of Edinburgh
Publications - 13
Citations - 260
J. I. Mason is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Adrenal cortex & Zona reticularis. The author has an hindex of 9, co-authored 13 publications receiving 252 citations.
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Journal ArticleDOI
Regulation of cholesterol metabolism in rat adrenal mitochondria.
TL;DR: It is suggested that translocation of cholesterol between different sterol pools occurs within the mitochondria, and potential intracellular effectors that could be of importance in the movement or regulation of mitochondrial cholesterol include bivalent metallic ions, prostaglandins, cyclic nucleotides, polyamines and polylysine.
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Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity
TL;DR: It is suggested that the glycyrrhetinic acid constituent of liquorice increases circulating and thereby, salivary levels of unconjugated deoxycorticosterone and dehydroepiandrosterone by inhibiting their conjugation at source within the adrenal cortex.
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Acute regulation of the bovine gene for the steroidogenic acute regulatory protein in ovarian theca and adrenocortical cells.
Richard Ivell,G. Tillmann,H Wang,M Nicol,Paul M. Stewart,Bettina Bartlick,Norbert Walther,J. I. Mason,Steven D. Morley +8 more
TL;DR: Kinetic analysis of the results indicated that the acute transcriptional response resides within the proximal (-315 bp) promoter region, which includes two putative responsive elements for the steroidogenic factor-1.
Journal ArticleDOI
Adrenarche is associated with decreased 3β-hydroxysteroid dehydrogenase expression in the adrenal reticularis
Jennifer S. Gell,Baron Atkins,Linda R. Margraf,J. I. Mason,Hironobu Sasano,William E. Rainey,Bruce R. Carr +6 more
TL;DR: It is suggested that as children mature there is a decreased level of 3 beta HSD in the adrenal reticularis which may contribute to the increased production of DHEA and DHEAS seen during adrenarche.
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The role of cholesterol and cytochrome P-450 in the cholesterol side chain cleavage reaction in adrenal cortex and corpora lutea.
TL;DR: It seems clear that the micro-environment of the cholesterol (?phospholipid) cytochrome P-450 in the cristae may be a significant factor in the ultimateRate limiting event in the overall cholesterol side chain cleavage oxygenase reaction.