Showing papers in "Journal of Steroid Biochemistry in 1975"

TL;DR: Following termination of the medication, the various symptoms of virilism reappeared more or less quickly and markedly in the majority of the patients unless they are placed on oral contraceptives containing a derivative of 17-acetoxyprogesterone.

TL;DR: It is now apparent that steroids induce de novo synthesis of both messenger RNA (mRNA) and ribosomal RNA (rRNA); the role of the former in directing the synthesis of specific proteins is reasonably clear but that of the latter remains to be elucidated.

TL;DR: A survey of steroidal compounds has revealed that 5α-reduced androstenedione is a potent competitive inhibitor which may be of physiologic importance in control of ovarian estrogen synthesis and 1-ene-testololactone is effective both in vitro and in vivo suggesting that antitumor activity of steroidsal drugs may be due to inhibition of estrogen synthesis rather than direct androgen action.

TL;DR: Modifications of partition column chromatography techniques have allowed the simultaneous elution of 7 plasma steroids using celite columns 5 cm.

TL;DR: The response of the uterus to a variety of physiological and pathological stimuli appears to center invariably on the release of PGF 2α (and possibly other PGs) and evidence exists that this event is wholly or partially dependent on the endogenous steroid status of the animal.

TL;DR: It is revealed that the introduction of double bonds and substituents into Alphaxalone modify its anaesthetic activity, as determined in mice, and these modifications are discussed with particular reference to the conformation of the A-ring.

TL;DR: The antisera obtained have been used by many investigators, including us, as specific binding reagents in the radioimmunoassay of these steroids in biological fluids.

TL;DR: It is believed that the classical concept of androgen action must be enlarged to encompass central effects that require the aromatization of androgens as well as those requiring ring A reduction.

TL;DR: High affinity progesterone binding proteins having the characteristics of steroid receptors were found in the endometrial and myometrial cytosols of human uteri obtained after hysterectomy from fertile females and estrogen-treated postmenopausal women.

TL;DR: Cyproterone acetate therapy has proved itself to be a valuable aid in psychotherapy of sexual deviations and perversions in that the perverse cycle is interrupted and a “sexual calm” is created as a starting point for psychotherapy.

TL;DR: High resolution mass fragmentography of steroid trimethylsilyl ethers, a technique having great specificity and sensitivity, is described, which enabled unequivocal identification and quantitation of the particular steroids of interest in crude tissue and plasma extracts, without recourse to prior purification.

TL;DR: Evidence indicates that a continuum of sensitivity to sex steroids exists and the deterioration of glucose tolerance appears to parallel the preexisting state of pancreatic beta cell function, suggesting an acquired form of subclinical diabetes in normal women on conventional contraceptive steroids which is reversible upon discontinuation.

TL;DR: A unitary hypothesis is discussed according to which the primary action of glucocorticoids consists in inhibiting cell growth while allowing the concomitant expression of specific enzymes.

TL;DR: The results of studies of ACTH-cortisol periodicity in patients with localized CNS disease or ocular blindness support the thesis of a neural origin of suchperiodicity, and animal studies indicate that altered feeding schedules can alter the phase of corticosteroid periodicity, perhaps by alteration of the sleep-wake cycle.

TL;DR: It is proposed that the regulation of P secretion during the early stages of the cycle controls the timing of the normal periodic gonadotropin release.

TL;DR: If ovariectomy is performed at 40 days of age, no mammary tumors develop, thus indicating that ovary-independent alterations are not induced in the mammary gland, as they are in the vagina, by high doses of estrogen or androgen administered neonatally.

TL;DR: During this phase, the concentrations of the two C-21 steroids were similar and at a low level: there was no evidence of a surge in the plasma concentrations of either steroid and the concentrations do not seem to be related to that of oestradiol-17β prior to ovulation.

TL;DR: Steroid inactivation by binding in female trout plasma has been studied and the induction of maturation trout oocytes in vitro by 17α-hydroxy-20β-dihydroprogesterone has been used as biological assay.

TL;DR: It is proposed that the interaction of steroid-receptor complexes with the nuclear acceptor is not a limiting factor in steroid hormone action since at all hormone concentrations a constant proportion of the complexes are bound to the nuclei.

TL;DR: It is postulated that androgens can act in the brain through its interaction with 5α-dihydrotestosterone receptors in a way similar to that in the peripheral target organs.

TL;DR: It is demonstrated that androgen exchange activity exists in both Sertoli cell and germ cell fractions and suggested that the mechanism of action of androgens in the testis may involve interaction with more than one cell type.

TL;DR: It seems likely that these well documented effects of ampicillin on urinary steroid excretion are caused by an interruption of the enterohepatic circulation of steroids which results from the inhibition of intestinal steroid metabolism described above.

TL;DR: This finding suggests that obesity increases the apparent “threshold” at which hirsutism appears in response to androgen or that obesity is a result of slight hyperandrogenism.

TL;DR: In this article, the percentage of the [ 3 H]-estradiol-17β metabolized was measured by incubating with endometrium obtained at different times during the menstrual cycle.

TL;DR: The primary advantage of running studies in parallel on several receptors resides in the possibility of classifying the anti-hormones according to whether they possess affinity for a given receptor, thus providing a criterion for the selection of highly specific compounds virtually devoid of hormonal side-effects.

TL;DR: The ovary of the rat was found to contain and secrete several 5α-pregnane derivatives with pronounced anaesthetic properties that can be produced in quantities similar to or even larger than those of progesterone.

TL;DR: Plasma P and 17-OHP from pregnant women from 11th to 40th post-ovulatory days are significantly higher than that from women in the last luteal phase (26–30 days of cycle), which indicates that serial determinations of these two steroids, after the 13th post/ovulatory day can contribute to the diagnosis of pregnancy.

TL;DR: The anterior pituitary of normal female rats shows a considerable 5α-reductase activity, which is much higher than that of male animals on day 14 of life, and this activity becomes very similar to that of normal males of the same age.

TL;DR: The administration of estradiol to hormone-deprived animals results in a “depletion-replenishment” sequence of receptor levels, which is caused by irreversible utilization and resynthesis of receptors, and Estradiol thus appears to enhance the rate of receptor synthesis.

TL;DR: Determinations by mass fragmentography are applied to the specific determination of oestrogens, testosterone, 5α-dihydrotestosterone, cortisol and aldosterone in human plasma.