J
J. O. Van Hemel
Researcher at Erasmus University Rotterdam
Publications - 32
Citations - 1382
J. O. Van Hemel is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Chromosomal translocation & Trisomy. The author has an hindex of 17, co-authored 32 publications receiving 1354 citations.
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Journal ArticleDOI
Genetic risk factors in infertile men with severe oligozoospermia and azoospermia
Gert R. Dohle,D. J. J. Halley,J. O. Van Hemel,A.M.W. van den Ouwel,M.H.E.C. Pieters,R. F. A. Weber,Lutgarde C.P. Govaerts +6 more
TL;DR: A genetic abnormality was identified in 36/150 (24%) men with extreme oligozoospermia and azoospermia, which can result in offspring with an enhanced risk of unbalanced chromosome complement, male infertility due to the transmission of a Y-chromosomal microdeletion, and cystic fibrosis if both partners are CFTR gene mutation carriers.
Journal ArticleDOI
Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after intracytoplasmic sperm injection
D. Van Opstal,Frans J. Los,S. Ramlakhan,J. O. Van Hemel,A. M. W. Van Den Ouweland,Helen Brandenburg,M. H. E. C. Pieters,Arie Verhoeff,M. C. S. Vermeer,Marc Dhont,P. In't Veld +10 more
TL;DR: Prenatal cytogenetic analysis of 71 fetuses conceived by intracytoplasmic sperm injection resulted in the detection of nine chromosome aberrations including two cases of 47,XXY, four cases involving a 45,X cell line and three autosomal trisomies.
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Chromosome studies in 1792 males prior to intra-cytoplasmic sperm injection : the Dutch experience
Joep H. A. M. Tuerlings,A. J. H. Hamers,Roel Hordijk,J. O. Van Hemel,Kerstin Hansson,J.M.N. Hoovers,K. Madan,M. van der Blij-Philipsen,K. B. J. Gerssen-Schoorl,Jan A.M. Kremer,Dominique Smeets +10 more
TL;DR: A nationwide cytogenetic study is performed to assess the frequency of chromosomal aberrations in male ICSI candidates, finding that of the 1792 males examined, 72 (4.0%) revealed a chromosomal aberration, and one individual even had two.
Journal ArticleDOI
Marker chromosomes in A series of 10000 prenatal diagnoses. Cytogenetic and follow-up studies
TL;DR: It is concluded that it seems safe to continue the pregnancy in cases of a familial marker, identical to that of one parent, whilst a de novo DA‐DAPI positive marker seems to present a low risk for fetal anomalies.
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Clinical and molecular studies in fragile X patients with a Prader-Willi-like phenotype.
B. B. A. De Vries,J. P. Fryns,M. G. Butler,F. Canziani,E. Wesby-van Swaay,J. O. Van Hemel,Ben A. Oostra,D. J. J. Halley,M. F. Niermeijer +8 more
TL;DR: Clinical and molecular findings illustrate the necessity to perform DNA analysis of the FMR-1 gene in mentally retarded patients presenting with a PW phenotype but without the PWS specific cytogenetic/molecular abnormalities of chromosome 15.