J
J. Ray Biffin
Researcher at University of Sydney
Publications - 4
Citations - 648
J. Ray Biffin is an academic researcher from University of Sydney. The author has contributed to research in topics: Molecule & Copper. The author has an hindex of 3, co-authored 3 publications receiving 613 citations.
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Journal ArticleDOI
Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized
Jane E. Weder,Carolyn T. Dillon,Trevor W. Hambley,Brendan J. Kennedy,Peter A. Lay,J. Ray Biffin,Hubert Leonardus Regtop,Neal M. Davies +7 more
TL;DR: If the potential opportunities of the Cu-NSAIDs are to be completely realized, a mechanistic understanding and delineation of their in vivo and in vitro pharmacological activity is fundamental, along with further characterization of their pharmacokinetic/pharmacodynamic disposition.
Journal ArticleDOI
Gastrointestinal toxicity, antiinflammatory activity, and superoxide dismutase activity of copper and zinc complexes of the antiinflammatory drug indomethacin.
Carolyn T. Dillon,Trevor W. Hambley,Brendan J. Kennedy,Peter A. Lay,Qingdi Zhou,Neal M. Davies,J. Ray Biffin,Hubert Leonardus Regtop +7 more
TL;DR: Cu2(Indo)4(DMF)2 exhibited the most promising results of the Indo complexes assayed, in that it exhibited SOD activity and the lowest gastrointestinal damage while also exhibiting antiinflammatory activity that was comparable to that for IndoH.
Journal ArticleDOI
Preparation and characterization of dinuclear copper–indomethacin anti-inflammatory drugs
Ying R Morgan,Peter Turner,Brendan J. Kennedy,Trevor W. Hambley,Peter A. Lay,J. Ray Biffin,Hubert Leonardus Regtop,Barry Warwick +7 more
TL;DR: In this paper, the crystal and molecular structures of the ternary copper-indomethacin complexes [Cu2(Indo)4L2] (IndoH=indometHacin=1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid; L=acetonitrile (AN), N,N-dimethylacetamide (DMA), tetrahydrofuran (THF), or pyridine (Py)) are reported.
Journal ArticleDOI
Vitamin K: history, metabolism, and nutrition in the horse
TL;DR: Vitamin K has long been known for its essential role in blood coagulation and has been considered a single-function "haemostasis vitamin" but rather as a "multi-function vitamin" as discussed by the authors .