J
J. Vicente Castell
Researcher at University of Valencia
Publications - 2
Citations - 439
J. Vicente Castell is an academic researcher from University of Valencia. The author has contributed to research in topics: Gene expression & Regulation of gene expression. The author has an hindex of 2, co-authored 2 publications receiving 417 citations.
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Journal ArticleDOI
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells.
Cristina Rodríguez-Antona,María Teresa Donato,Alan R. Boobis,Robert J. Edwards,Patricia S. Watts,J. Vicente Castell,M.-J. Gómez-Lechón +6 more
TL;DR: The loss of biotransformation activity in cultured hepatic cells is caused by a decrease in CYP transcription, which correlates with an alteration in the expression of key transcription factors.
Journal ArticleDOI
Cryopreservation of rat, dog and human hepatocytes: influence of preculture and cryoprotectants on recovery, cytochrome P450 activities and induction upon thawing.
TL;DR: The results suggest that the cryopreserved hepatocytes in a medium containing polyvinylpyrrolidone (PVP), in addition to DMSO, constitutes a convenient means of long-term storage of hepatocytes for preparing primary cultures to be used in drug metabolism studies.