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Robert J. Edwards
Researcher at University of London
Publications - 47
Citations - 2298
Robert J. Edwards is an academic researcher from University of London. The author has contributed to research in topics: Cytochrome P450 & Cytochrome. The author has an hindex of 24, co-authored 47 publications receiving 2254 citations. Previous affiliations of Robert J. Edwards include University of Cambridge.
Papers
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Journal ArticleDOI
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells.
Cristina Rodríguez-Antona,María Teresa Donato,Alan R. Boobis,Robert J. Edwards,Patricia S. Watts,J. Vicente Castell,M.-J. Gómez-Lechón +6 more
TL;DR: The loss of biotransformation activity in cultured hepatic cells is caused by a decrease in CYP transcription, which correlates with an alteration in the expression of key transcription factors.
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A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking.
TL;DR: It is concluded that the high affinity component of phenacetin O-deethylase activity in man is catalysed by the orthologue of rat cytochrome P450d, and that this isoenzyme is inducible by cigarette smoking.
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Expression of xenobiotic-metabolizing cytochrome P450 Forms in human full-term placenta
Jukka Hakkola,Markku Pasanen,Janne Hukkanen,Olavi Pelkonen,Jukka Mäenpää,Robert J. Edwards,Alan R. Boobis,Hannu Raunio +7 more
TL;DR: Data show that several xenobiotic-metabolizing CYP genes are expressed in human placenta at a low level, and the significant of such low-level expression is unknown, but it may have local physiological or toxic consequences.
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Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human
Robert J. Edwards,Bernard P. Murray,Stephen Murray,Thomas Schulz,Dither Neubert,Timothy W. Gant,Snorri S. Thorgeirsson,Alan R. Boobis,Donald S. Davies +8 more
TL;DR: Marmoset monkey may be a more suitable model than the cynomolgus monkey for carcinogenicity studies involving MeIQx and PhIP, but not IQ, and the hepatic metabolism of heterocyclic amines by CYP1A enzymes in the untreated marmoset monkeys resembles that in human more closely than that in man.
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Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors
Alan R. Boobis,D. Sesardic,Bernard P. Murray,Robert J. Edwards,Alison M. Singleton,K. J. Rich,Stephen Murray,R. de la Torre,Jordi Segura,Olavi Pelkonen,M. Pasanen,Shinichi Kobayashi,T. Zhi-guang,Donald S. Davies +13 more
TL;DR: The differences between species in their response to inducers and inhibitors make extrapolation to humans from the results of animal studies difficult, so that ultimately such effects should be studied in the species of interest, humans.