J
Jacek Karczewski
Researcher at Poznan University of Medical Sciences
Publications - 64
Citations - 2206
Jacek Karczewski is an academic researcher from Poznan University of Medical Sciences. The author has contributed to research in topics: Kidney transplantation & Transplantation. The author has an hindex of 16, co-authored 56 publications receiving 1776 citations.
Papers
More filters
Journal ArticleDOI
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
Wolfgang Hueber,Bruce E. Sands,Steve Lewitzky,Marc Vandemeulebroecke,Walter Reinisch,Peter D.R. Higgins,Jan Wehkamp,Brian G. Feagan,Michael D Yao,Marek Karczewski,Jacek Karczewski,Nicole Pezous,Stephan Bek,Gerard Bruin,Bjoern Mellgard,Claudia Berger,Marco Londei,Arthur P. Bertolino,Gervais Tougas,Simon Travis +19 more
TL;DR: Blockade of IL-17A was ineffective and higher rates of adverse events were noted compared with placebo, and unfavourable responses on secukinumab were driven by patients with elevated inflammatory markers.
Journal ArticleDOI
Obesity and inflammation
Jacek Karczewski,Ewelina Śledzińska,Alina Baturo,Izabela Jończyk,Aleksander Maleszko,Paweł Samborski,Beata Begier-Krasińska,Agnieszka Dobrowolska +7 more
TL;DR: The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others.
Journal ArticleDOI
New insights into the role of T cells in pathogenesis of psoriasis and psoriatic arthritis
TL;DR: Current data strongly suggest that both PsO and PsA are T cell-mediated diseases, with a key role of various proinflammatory cytokines in their development.
Journal ArticleDOI
Role of TH1/TH2 cytokines in kidney allograft rejection.
TL;DR: Higher pretransplantation levels of IFN-gamma and IL-10 observed in ARE patients indicated ongoing nondetected, probably nonspecific, inflammatory processes able to intensify an immune response directed against the transplanted organ leading to its acute rejection.
Journal ArticleDOI
The effects of the microbiota on the host immune system
TL;DR: This review is focused on influence of bacterial-derived signals on immune cell function and the mechanisms by which these signals modulate the development and progression of inflammatory and autoimmune diseases.