G
Gerard Bruin
Researcher at Novartis
Publications - 50
Citations - 5788
Gerard Bruin is an academic researcher from Novartis. The author has contributed to research in topics: Secukinumab & Capillary electrophoresis. The author has an hindex of 24, co-authored 46 publications receiving 5381 citations. Previous affiliations of Gerard Bruin include University of Amsterdam.
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Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
Wolfgang Hueber,Bruce E. Sands,Steve Lewitzky,Marc Vandemeulebroecke,Walter Reinisch,Peter D.R. Higgins,Jan Wehkamp,Brian G. Feagan,Michael D Yao,Marek Karczewski,Jacek Karczewski,Nicole Pezous,Stephan Bek,Gerard Bruin,Bjoern Mellgard,Claudia Berger,Marco Londei,Arthur P. Bertolino,Gervais Tougas,Simon Travis +19 more
TL;DR: Blockade of IL-17A was ineffective and higher rates of adverse events were noted compared with placebo, and unfavourable responses on secukinumab were driven by patients with elevated inflammatory markers.
Journal ArticleDOI
Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis
Wolfgang Hueber,Dhavalkumar D. Patel,Thaddeus P. Dryja,Andrew M Wright,Irina Koroleva,Gerard Bruin,Christian Antoni,Zoe Diana Draelos,Michael H. Gold,Patrick Durez,Paul P. Tak,Juan J. Gomez-Reino,C. Stephen Foster,Rosa Y. Kim,C. Michael Samson,Naomi S. Falk,David S. Chu,David Callanan,Quan Dong Nguyen,Kristine Rose,Asifa Haider,Franco Di Padova +21 more
TL;DR: The results demonstrate that IL-17A participates in psoriasis, rheumatoid arthritis, and uveitis and that the antibody against this cytokine may be an effective therapeutic agent, and warrant larger clinical trials to assess further the safety and efficacy of AIN457.
Supplementary Materials for Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis
Wolfgang Hueber,Dhavalkumar D. Patel,Thaddeus P. Dryja,Andrew M Wright,Gerard Bruin,Christian Antoni,Michael H. Gold,Patrick Durez,Paul P. Tak,Juan J. Go,C. Stephen Foster,Rosa Y. Kim,C. Michael Samson,Naomi S. Falk,David S. Chu,David Callanan,Asifa Haider +16 more
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Integrated capillary electrophoresis on flexible silicone microdevices: analysis of DNA restriction fragments and detection of single DNA molecules on microchips
TL;DR: High single-molecule detection efficiency was achieved under electrophoretically controlled mass transport conditions in PDMS microchannels and single λ-DNA molecules intercalated with YOYO-1 at a base pair-to-dye ratio of 10:1 could be detected with an uncomplicated laser-induced fluorescence detection setup.
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Recent developments in electrokinetically driven analysis on microfabricated devices.
TL;DR: This review is devoted to the rapid developments in the field of microfluidic separation devices in which the flow is electrokinetically driven, and where the separation element forms the heart of the system, in order to give an overview of the trends of the last three years.